Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects
Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, a...
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| Published in | PloS one Vol. 11; no. 1; p. e0145811 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
07.01.2016
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0145811 |
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| Abstract | Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status.
427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used.
BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda.
Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects. |
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| AbstractList | Introduction Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. Methods 427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m.sup.2 ] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20[greater than or equal to]FLI<60, and FLI[greater than or equal to]60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used. Results BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI[greater than or equal to]60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda. Conclusions Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects. Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. 427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m.sup.2 ] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20[greater than or equal to]FLI<60, and FLI[greater than or equal to]60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used. BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI[greater than or equal to]60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda. Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects. Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status.INTRODUCTIONRecently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status.427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used.METHODS427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used.BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda.RESULTSBMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda.Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects.CONCLUSIONSImpairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects. Introduction Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. Methods 427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m 2 ] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used. Results BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda. Conclusions Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects. INTRODUCTION:Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. METHODS:427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used. RESULTS:BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda. CONCLUSIONS:Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects. Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. 427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used. BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda. Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects. |
| Audience | Academic |
| Author | Gnessi, Lucio Lenzi, Andrea Poggiogalle, Eleonora Mariani, Stefania Donini, Lorenzo Maria Lubrano, Carla |
| AuthorAffiliation | Department of Experimental Medicine- Medical Pathophysiology, Food Science and Endocrinology Section, “Sapienza” University of Rome, Rome, Italy Dasman Diabetes Institute, KUWAIT |
| AuthorAffiliation_xml | – name: Dasman Diabetes Institute, KUWAIT – name: Department of Experimental Medicine- Medical Pathophysiology, Food Science and Endocrinology Section, “Sapienza” University of Rome, Rome, Italy |
| Author_xml | – sequence: 1 givenname: Eleonora surname: Poggiogalle fullname: Poggiogalle, Eleonora – sequence: 2 givenname: Carla surname: Lubrano fullname: Lubrano, Carla – sequence: 3 givenname: Lucio surname: Gnessi fullname: Gnessi, Lucio – sequence: 4 givenname: Stefania surname: Mariani fullname: Mariani, Stefania – sequence: 5 givenname: Andrea surname: Lenzi fullname: Lenzi, Andrea – sequence: 6 givenname: Lorenzo Maria surname: Donini fullname: Donini, Lorenzo Maria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26741958$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/hep.22845 10.1530/EJE-10-0365 10.1210/jc.2011-1227 10.1016/j.cger.2011.03.007 10.1016/j.jamda.2011.01.003 10.1507/endocrj.EJ12-0322 10.1371/journal.pone.0044136 10.1093/ajcn/52.2.214 10.1007/s12349-013-0135-1 10.1249/00005768-199208000-00020 10.1016/j.metabol.2010.07.024 10.1161/ATVBAHA.114.303034 10.1038/sj.ijo.0800741 10.1111/j.1365-2265.2012.04433.x 10.1007/s12020-014-0315-x 10.1056/NEJMra1011035 10.1530/EJE-09-0374 10.1016/j.clnu.2012.06.010 10.1186/1471-230X-6-33 10.1210/jc.2011-0435 10.1016/S1262-3636(05)73648-X 10.1677/JOE-09-0431 10.1177/0148607111413773 10.1002/jcsm.12030 10.4093/dmj.2013.37.4.278 10.1002/hep.26716 10.2337/diacare.22.9.1462 10.1046/j.1532-5415.2002.50216.x 10.1210/jc.2009-0438 10.1530/EJE-14-0112 10.1007/s12020-015-0530-0 10.1038/nrendo.2013.67 10.1002/hep.27058 10.1016/j.bpg.2014.07.008 10.1111/jgh.12437 10.1530/eje.1.02211 10.1038/nrendo.2013.64 10.2337/dc10-0107 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: EP CL LG LMD. Performed the experiments: CL SM. Analyzed the data: EP LMD. Contributed reagents/materials/analysis tools: SM LG. Wrote the paper: EP CL LG LMD. Contributed to the interpretation of the results: AL LG. Competing Interests: The authors have declared that no competing interests exist. |
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| References | MA Bredella (ref25) 2009; 94 P Dietrich (ref5) 2014; 28 L Xu (ref14) 2012; 7 GI Shulman (ref8) 2014; 371 CD Byrne (ref30) 2014; 34 Y Takahashi (ref13) 2012; 59 LM Donini (ref34) 2013; 6 RA Fielding (ref2) 2011; 12 TN Kim (ref35) 2013; 78 JS Moon (ref6) 2013; 37 C Lubrano (ref12) 2015; 49 G Bedogni (ref23) 2006; 6 DL Waters (ref1) 2011; 27 D Gallagher (ref32) 2011; 35 MM Guichelaar (ref17) 2014; 59 E Gielen (ref39) 2015; 6 DE Berryman (ref10) 2013; 9 SB Heymsfield (ref20) 1990; 52 M Matsuda (ref22) 1999; 22 DJ Cuthbertson (ref38) 2014; 171 S Martinez-Hervas (ref29) 2011; 60 SS Runchey (ref28) 2014; 29 A Gastaldelli (ref24) 2009; 49 C Guillet (ref31) 2005; 31 I Janssen (ref37) 2002; 50 F Arturi (ref26) 2011; 96 M Siervo (ref21) 2014; 15 H Völzke (ref27) 2009; 161 S Lim (ref36) 2010; 33 C Franco (ref15) 2006; 155 P Srikanthan (ref9) 2011; 96 CM Prado (ref4) 2012; 31 P Deurenberg (ref18) 1998; 22 RK Junnila (ref16) 2013; 9 E Poggiogalle (ref3) 2014; 47 HC Hong (ref7) 2014; 59 TJ Lohman (ref19) 2002; 24 DJ Brick (ref11) 2010; 163 S Perrini (ref33) 2010; 205 |
| References_xml | – volume: 49 start-page: 1537 year: 2009 ident: ref24 article-title: Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population publication-title: Hepatology doi: 10.1002/hep.22845 – volume: 163 start-page: 185 year: 2010 ident: ref11 article-title: Determinants of IGF1 and GH across the weight spectrum: from anorexia nervosa to obesity publication-title: Eur J Endocrinol doi: 10.1530/EJE-10-0365 – volume: 96 start-page: E1640 year: 2011 ident: ref26 article-title: Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor-I publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-1227 – volume: 27 start-page: 401 year: 2011 ident: ref1 article-title: Sarcopenia and obesity publication-title: Clin Geriatr Med doi: 10.1016/j.cger.2011.03.007 – volume: 12 start-page: 249 year: 2011 ident: ref2 article-title: Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia publication-title: J Am Med Dir Assoc doi: 10.1016/j.jamda.2011.01.003 – volume: 59 start-page: 955 year: 2012 ident: ref13 article-title: Essential roles of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the liver publication-title: Endocr J doi: 10.1507/endocrj.EJ12-0322 – volume: 7 start-page: e44136 year: 2012 ident: ref14 article-title: Association between serum growth hormone levels and nonalcoholic fatty liver disease: a cross-sectional study publication-title: PLoS One doi: 10.1371/journal.pone.0044136 – volume: 52 start-page: 214 year: 1990 ident: ref20 article-title: Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry publication-title: Am J Clin Nutr doi: 10.1093/ajcn/52.2.214 – volume: 6 start-page: 191 year: 2013 ident: ref34 article-title: Body composition in sarcopenic obesity: systematic review of the literature publication-title: Mediterr J Nutr Metab doi: 10.1007/s12349-013-0135-1 – volume: 24 start-page: 952 year: 2002 ident: ref19 article-title: Antropometric standardization reference manual publication-title: Med Sci Sports Exerc doi: 10.1249/00005768-199208000-00020 – volume: 60 start-page: 740 year: 2011 ident: ref29 article-title: Misclassification of subjects with insulin resistance and associated cardiovascular risk factors by homeostasis model assessment index. Utility of a postprandial method based on oral glucose tolerance test publication-title: Metabolism doi: 10.1016/j.metabol.2010.07.024 – volume: 34 start-page: 1155 year: 2014 ident: ref30 article-title: Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.114.303034 – volume: 22 start-page: 1164 year: 1998 ident: ref18 article-title: Body mass index and percent body fat: a meta analysis among different ethnic groups publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0800741 – volume: 78 start-page: 525 year: 2013 ident: ref35 article-title: Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2012.04433.x – volume: 47 start-page: 699 year: 2014 ident: ref3 article-title: Treatment of body composition changes in obese and overweight older adults: insight into the phenotype of sarcopenic obesity publication-title: Endocrine doi: 10.1007/s12020-014-0315-x – volume: 371 start-page: 1131 year: 2014 ident: ref8 article-title: Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease publication-title: N Engl J Med doi: 10.1056/NEJMra1011035 – volume: 161 start-page: 705 year: 2009 ident: ref27 article-title: Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample publication-title: Eur J Endocrinol doi: 10.1530/EJE-09-0374 – volume: 31 start-page: 583 year: 2012 ident: ref4 article-title: Sarcopenic obesity: A Critical appraisal of the current evidence publication-title: Clin Nutr doi: 10.1016/j.clnu.2012.06.010 – volume: 6 start-page: 33 year: 2006 ident: ref23 article-title: The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population publication-title: BMC Gastroenterol doi: 10.1186/1471-230X-6-33 – volume: 96 start-page: 2898 year: 2011 ident: ref9 article-title: Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-0435 – volume: 31 start-page: 5S20 year: 2005 ident: ref31 article-title: Insulin resistance: a contributing factor to age-related muscle mass loss? publication-title: Diabetes Metab doi: 10.1016/S1262-3636(05)73648-X – volume: 205 start-page: 201 year: 2010 ident: ref33 article-title: The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis publication-title: J Endocrinol doi: 10.1677/JOE-09-0431 – volume: 35 start-page: 21S year: 2011 ident: ref32 article-title: Body composition (sarcopenia) in obese patients: implications for care in the intensive care unit publication-title: JPEN J Parenter Enteral Nutr doi: 10.1177/0148607111413773 – volume: 15 start-page: 1 year: 2014 ident: ref21 article-title: Body composition indices of a load-capacity model: gender- and BMI-specific reference curves publication-title: Public Health Nutr – volume: 6 start-page: 242 year: 2015 ident: ref39 article-title: Endocrine determinants of incident sarcopenia in middle-aged and elderly European men publication-title: J Cachexia Sarcopenia Muscle doi: 10.1002/jcsm.12030 – volume: 37 start-page: 278 year: 2013 ident: ref6 article-title: The role of skeletal muscle in development of nonalcoholic Fatty liver disease publication-title: Diabetes Metab J doi: 10.4093/dmj.2013.37.4.278 – volume: 59 start-page: 1772 year: 2014 ident: ref7 article-title: Relationship between sarcopenia and nonalcoholic fatty liver disease: the Korean Sarcopenic Obesity Study publication-title: Hepatology doi: 10.1002/hep.26716 – volume: 22 start-page: 1462 year: 1999 ident: ref22 article-title: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp publication-title: Diabetes Care doi: 10.2337/diacare.22.9.1462 – volume: 50 start-page: 889 year: 2002 ident: ref37 article-title: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability publication-title: J Am Geriatr Soc doi: 10.1046/j.1532-5415.2002.50216.x – volume: 94 start-page: 3995 year: 2009 ident: ref25 article-title: Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-0438 – volume: 171 start-page: 561 year: 2014 ident: ref38 article-title: External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals publication-title: Eur J Endocrinol doi: 10.1530/EJE-14-0112 – volume: 49 start-page: 503 year: 2015 ident: ref12 article-title: Severe growth hormone deficiency and empty sella in obesity: a cross-sectional study publication-title: Endocrine doi: 10.1007/s12020-015-0530-0 – volume: 9 start-page: 366 year: 2013 ident: ref16 article-title: The GH/IGF-1 axis in ageing and longevity publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2013.67 – volume: 59 start-page: 1668 year: 2014 ident: ref17 article-title: Decreased muscle mass in nonalcoholic fatty liver disease: new evidence of a link between growth hormone and fatty liver disease? publication-title: Hepatology doi: 10.1002/hep.27058 – volume: 28 start-page: 637 year: 2014 ident: ref5 article-title: Non-alcoholic fatty liver disease, obesity and the metabolic syndrome publication-title: Best Pract Res Clin Gastroenterol doi: 10.1016/j.bpg.2014.07.008 – volume: 29 start-page: 589 year: 2014 ident: ref28 article-title: Relationship between serum circulating insulin-like growth factor-1 and liver fat in the United States publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.12437 – volume: 155 start-page: 261 year: 2006 ident: ref15 article-title: Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity publication-title: Eur J Endocrinol doi: 10.1530/eje.1.02211 – volume: 9 start-page: 346 year: 2013 ident: ref10 article-title: The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2013.64 – volume: 33 start-page: 1652 year: 2010 ident: ref36 article-title: Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA) publication-title: Diabetes Care doi: 10.2337/dc10-0107 |
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| Snippet | Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver... Introduction Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking... INTRODUCTION:Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking... Introduction Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking... |
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| SubjectTerms | Adult Analysis Body Composition Body composition (biology) Body fat Body mass Body Mass Index Deposition Dual energy X-ray absorptiometry Fatty liver Fatty Liver - complications Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - pathology Female Gene Expression Ghrelin - genetics Ghrelin - metabolism Glucose Growth hormone Growth hormones Humans Insulin Insulin Resistance Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Linear Models Liver Liver - metabolism Liver - pathology Male Middle Aged Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Obesity Obesity - complications Obesity - genetics Obesity - metabolism Obesity - pathology Physiological aspects Regression analysis Risk factors Sarcopenia Sarcopenia - complications Sarcopenia - genetics Sarcopenia - metabolism Sarcopenia - pathology Skeletal muscle Steatosis Womens health |
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| Title | Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects |
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