Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects

• Published in: PloS one Vol. 11; no. 1; p. e0145811
• Main Authors: Poggiogalle, Eleonora, Lubrano, Carla, Gnessi, Lucio, Mariani, Stefania, Lenzi, Andrea, Donini, Lorenzo Maria
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.01.2016; Public Library of Science (PLoS)
• Subjects: Adult; Analysis; Body Composition; Body composition (biology); Body fat; Body mass; Body Mass Index; Deposition; Dual energy X-ray absorptiometry; Fatty liver; Fatty Liver - complications; Fatty Liver - genetics; Fatty Liver - metabolism; Fatty Liver - pathology; Female; Gene Expression; Ghrelin - genetics; Ghrelin - metabolism; Glucose; Growth hormone; Growth hormones; Humans; Insulin; Insulin Resistance; Insulin-like growth factor I; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Linear Models; Liver; Liver - metabolism; Liver - pathology; Male; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Muscles; Obesity; Obesity - complications; Obesity - genetics; Obesity - metabolism; Obesity - pathology; Physiological aspects; Regression analysis; Risk factors; Sarcopenia; Sarcopenia - complications; Sarcopenia - genetics; Sarcopenia - metabolism; Sarcopenia - pathology; Skeletal muscle; Steatosis; Womens health; United States; Italy
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0145811

Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. 427 subjects [age: 45.65±13.94 years, BMI: 36.92±6.43 kg/m2] were enrolled. Participants were divided into three groups: fatty liver index (FLI) <20, 20≥FLI<60, and FLI≥60. Body composition was assessed by DXA. The truncal fat mass (TrFM) to appendicular skeletal muscle (ASM) ratio was used as an indicator of sarcopenic obesity. ISI-Matsuda index was used. BMI, fat mass, and the TrFM/ASM ratio were higher in subjects with FLI≥60. GH, IGF-1 and ISI-Matsuda were lower in the high FLI group (all p<0.05). A significantly positive correlation between FLI and TrFM/ ASM ratio (r = 0.221, p<0.001) was found, whereas FLI levels were negatively correlated with ISI- Matsuda (r = -0.335, p<0.001), GH (r = -0.200, p = 0.006), and IGF- 1 levels (r = -0.157, p = 0.028). Stepwise linear regression analysis showed that GH levels were significantly negatively correlated with FLI, while the TrFM/ ASM ratio was positively associated with FLI, after adjustment for age, BMI, total fat mass, truncal fat mass, fat- free mass, and ISI- Matsuda. Impairment of GH/IGF-1 axis seems to be associated to the risk of the development of sarcopenic obesity and ectopic fat deposition in the liver. Metabolic and hormonal derangements as determinants of ectopic fat deposition and body composition deserve to be evaluated in obese subjects.