Association of nasal septal deviation with the incidence of anxiety, depression, and migraine: A national population-based study

• Published in: PloS one Vol. 16; no. 11; p. e0259468
• Main Authors: Lee, Ki-Il, In, Seung Min, Kim, Jong-Yeup, Hong, Jee-Young, Han, Kyung-Do, Kim, Jung-Soo, Jung, Yong Gi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.11.2021; Public Library of Science (PLoS)
• Subjects: Adult; Age; Airway management; Anxiety; Anxiety - epidemiology; Anxiety disorders; Biology and Life Sciences; Care and treatment; Case-Control Studies; Comorbidity; Complications and side effects; Depression - epidemiology; Deviation; Diabetes; Diabetes mellitus; Diagnosis; Dyslipidemia; Endoscopy; Female; Gender; Headache; Health risks; Hospitals; Humans; Hypertension; Incidence; Informatics; Male; Medical examination; Medical research; Medical schools; Medical screening; Medicine; Medicine and Health Sciences; Mental depression; Metabolic disorders; Methods; Middle Aged; Migraine; Migraine Disorders - epidemiology; Nasal Obstruction - genetics; Nasal Obstruction - psychology; Nasal septum; Nasal Septum - abnormalities; Neuropsychology; Otolaryngology; Patients; Physicians; Population; Population studies; Population-based studies; Rank tests; Republic of Korea - epidemiology; Respiratory tract diseases; Retrospective Studies; Rhinitis; Rhinosinusitis; Risk factors; Social Sciences; Statistical analysis; Surgery; Republic of Korea; South Korea
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0259468

Nasal obstruction caused by nasal septal deviation is very bothersome and, therefore, can affect the patient's emotional state. However, little is known about the effect of nasal septal deviation (NSD) on the neuropsychiatric aspects of patients. Therefore, this study aims to verify the higher incidence of anxiety, depression, and migraine in patients diagnosed with NSD compared to general populations using big data. This retrospective cohort study collected subjects from the Korean National Health Insurance Service (NHIS) database. Adjustments were made to minimize the confounding of variables for age, sex, residence type, income levels, hypertension, diabetes, dyslipidemia, rhinitis, and chronic rhinosinusitis between the two groups. The primary endpoint of this study was newly diagnosed anxiety, depression, and migraine between January 2009 and December 2018. Kaplan-Meier survival curves, logarithmic rank test, and Cox proportional regression test were used for statistical analysis. Among a total of 135,769 subjects in the NHIS database, 48,495 patients with NSD (NSD group) and 54,475 control subjects (control group) were selected. Patients with NSD had an increased risk of anxiety, depression, and migraine compared to the control group. In the NSD group, the adjusted hazard ratios (HR) were 1.236 (95% CI, 1.198-1.276) for anxiety, 1.289 (95% CI, 1.238-1.343) for depression, and 1.251 (95% CI, 1.214-1.290) for migraine. NSD is associated with a higher incidence of anxiety, depression, and migraine. Therefore, it is suggested that physicians carefully consider psychoneurological distress and employ therapeutic strategies to minimize these conditions.