Early Experience after Developing a Pathology Laboratory in Malawi, with Emphasis on Cancer Diagnoses

• Published in: PloS one Vol. 8; no. 8; p. e70361
• Main Authors: Gopal, Satish, Krysiak, Robert, Liomba, N. George, Horner, Marie-Josephe, Shores, Carol G., Alide, Noor, Kamiza, Steve, Kampani, Coxcilly, Chimzimu, Fred, Fedoriw, Yuri, Dittmer, Dirk P., Hosseinipour, Mina C., Hoffman, Irving F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.08.2013; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; Age; AIDS; Biomedical laboratories; Breast cancer; Cancer; Cancer diagnosis; Cancer research; Cervical cancer; Cervix; Clinical Laboratory Services; Comorbidity; Cross-Sectional Studies; Early experience; Esophageal cancer; Esophagus; Female; Health risk assessment; HIV; HIV infections; HIV Infections - epidemiology; Hospitals; Human immunodeficiency virus; Humans; Infectious diseases; Laboratories; Laboratories, Hospital; Logistic Models; Lymphoma; Lymphomas; Malawi - epidemiology; Male; Malignancy; Medical diagnosis; Medicine; Middle Aged; Multivariate Analysis; Neoplasms - classification; Neoplasms - diagnosis; Neoplasms - epidemiology; Oncology; Pathology; Pathology, Clinical; Patients; Population; Precancerous Conditions - diagnosis; Precancerous Conditions - epidemiology; Prevalence; Registries - statistics & numerical data; Sarcoma; Time Factors; Young Adult; Malawi; North Carolina; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0070361

Despite increasing cancer burden in Malawi, pathology services are limited. We describe operations during the first 20 months of a new pathology laboratory in Lilongwe, with emphasis on cancer diagnoses. We performed a cross-sectional study of specimens from the Kamuzu Central Hospital pathology laboratory between July 1, 2011 and February 28, 2013. Patient and specimen characteristics, and final diagnoses are summarized. Diagnoses were categorized as malignant, premalignant, infectious, other pathology, normal or benign, or nondiagnostic. Patient characteristics associated with premalignancy and malignancy were assessed using logistic regression. Of 2772 specimens, 2758 (99%) with a recorded final diagnosis were included, drawn from 2639 unique patients. Mean age was 38 years and 63% were female. Of those with documented HIV status, 51% had unknown status, and 36% with known status were infected. Histologic specimens comprised 91% of cases, and cytologic specimens 9%. Malignant diagnoses were most common overall (n = 861, 31%). Among cancers, cervical cancer was most common (n = 117, 14%), followed by lymphoma (n = 91, 11%), esophageal cancer (n = 86, 10%), sarcoma excluding Kaposi sarcoma (n = 75, 9%), and breast cancer (n = 61, 7%). HIV status was known for 95 (11%) of malignancies, with HIV prevalence ranging from 9% for breast cancer to 81% for cervical cancer. Increasing age was consistently associated with malignancy [bivariable odds ratio 1.24 per decade increase (95% CI 1.19-1.29) among 2685 patients with known age; multivariable odds ratio 1.33 per decade increase (95% CI 1.14-1.56) among 317 patients with known age, gender, and HIV status], while HIV infection and gender were not. Despite selection and referral bias inherent in these data, a new pathology laboratory in Lilongwe has created a robust platform for cancer care and research. Strategies to effectively capture clinical information for pathologically confirmed cancers can allow these data to complement population-based registration.