Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

• Published in: Nature genetics Vol. 50; no. 10; pp. 1412 - 1425
• Main Authors: Mifsud, Borbala, Witkowska, Katarzyna, Tzanis, Evan, Velez Edwards, Digna R., Wilson, Peter W. F., Esko, Tonu, Almgren, Peter, Debette, Stéphanie, Li-Gao, Ruifang, Qian, Yong, Sargurupremraj, Muralidharan, Thériault, Sébastien, Verweij, Niek, Zhao, Jing-Hua, de Mutsert, Renée, Menni, Cristina, Paré, Guillaume, Poulter, Neil R., Ayers, Kristin L., Barbieri, Caterina M., Bis, Joshua C., Bochud, Murielle, Boomsma, Dorret I., Bottinger, Erwin P., Brumat, Marco, Campbell, Harry, Chakravarti, Aravinda, Ciullo, Marina, Cordell, Heather J., Davies, Gail, de Geus, Eco J., Deary, Ian J., Ehret, Georg B., Ferreira, Teresa, Franco, Oscar H., Gandin, Ilaria, Gasparini, Paolo, Goel, Anuj, Gow, Alan J., Gyllensten, Ulf, Harris, Sarah E., Hicks, Andrew A., Hofman, Albert, Hwang, Shih-Jen, James, Alan, Johansson, Åsa, Jukema, J. Wouter, Kähönen, Mika, Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Launer, Lenore J., Lehne, Benjamin, Liewald, David C. M., Lind, Lars, Liu, YongMei, Lopez, Lorna M., Lyytikäinen, Leo-Pekka, Marten, Jonathan, Morris, Andrew P., Nandakumar, Priyanka, Nolte, Ilja M., Nutile, Teresa, Oostra, Ben A., Padmanabhan, Sandosh, Penninx, Brenda W. J. H., Perola, Markus, Peters, Annette, Pramstaller, Peter P., Nguyen, Quang Tri, Raitakari, Olli T., Ren, Meixia, Rettig, Rainer, Ridker, Paul M., Ried, Janina S., Riese, Harriëtte, Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Smith, Albert V., Snieder, Harold, Sõber, Siim, Teumer, Alexander, Tomaszewski, Maciej, Toniolo, Daniela, Trompet, Stella, Tuomilehto, Jaakko, Vaez, Ahmad, van Duijn, Cornelia M., Vuckovic, Dragana, Wilson, James F., Yao, Jie, Zhang, Weihua, Attia, John R., Howson, Joanna M. M., O’Donnell, Christopher J., Edwards, Todd L., Psaty, Bruce M., Tzoulaki, Ioanna, Elliott, Paul
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2018; Nature Publishing Group
• Subjects: 45/43; 631/114/2785; 631/208/205/2138; 692/699/75; Adult; Aged; Aged, 80 and over; Agriculture; Animal Genetics and Genomics; Basic Medicine; Biomedical and Life Sciences; Biomedicine; Blood pressure; Blood Pressure - genetics; Cancer Research; Cardiology and Cardiovascular Disease; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - genetics; Cells, Cultured; Clinical Medicine; Consortia; Female; Gene Function; Gene loci; Genetic analysis; Genetic aspects; Genetic Loci; Genetic Predisposition to Disease; Genetic research; Genetic susceptibility; Genetic Testing - methods; Genetics, Population - methods; Genome-Wide Association Study; Genomes; Health aspects; Health risk assessment; Human Genetics; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Hypertension - genetics; Identification and classification; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; Life Style; Lifestyles; Male; Medical and Health Sciences; Medical Genetics and Genomics (including Gene Therapy); Medicin och hälsovetenskap; Medicinsk genetik och genomik (Här ingår: Genterapi); Medicinska och farmaceutiska grundvetenskaper; Meta-analysis; Middle Aged; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Risk analysis; Risk Factors; Studies; Vascular diseases; United Kingdom; United Kingdom > UK
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/s41588-018-0205-x

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.