Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two

In autism spectrum disorder (ASD), medical conditions in infancy could be predictive markers for later ASD diagnosis. In this study, electronic medical records of 579 autistic individuals and 1897 matched controls prior to age 2 were analyzed for potential predictive conditions. Using a novel tool,...

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Bibliographic Details
Published in	Journal of autism and developmental disorders Vol. 53; no. 6; pp. 2540 - 2547
Main Authors	Eyoh, Ekomobong E., Failla, Michelle D., Williams, Zachary J., Schwartz, Kyle L., Cutting, Laurie E., Landman, Bennett A., Cascio, Carissa J.
Format	Journal Article
Language	English
Published	New York Springer US 01.06.2023 Springer Springer Nature B.V
Subjects	Age Alaska Natives Autism Autism Spectrum Disorder - complications Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - epidemiology Autism Spectrum Disorders Autistic children Autistic Disorder - complications Behavioral Science and Psychology Behavioral Sciences Body Weight Brief Report Child Child and School Psychology Child Development Child, Preschool Children Codes College Science Comorbidity Complications and side effects Computerized medical records Control Groups Delayed Departments Developmental delays Diagnosis Electronic Equipment Electronic health records Electronic medical records Epilepsy Evaluation Eye Movements Female Group Membership Health aspects Humans Infancy Jaundice Literary Devices Mann-Whitney U test Medical conditions Medical diagnosis Medical records Medical screening Mortality Neurosciences Nystagmus Patients Pediatrics Perinatal Pervasive developmental disorders Pregnancy Psychology Public Health Records (Forms) Regression (Statistics) Relative association Strabismus United States Visual Impairments United States Autism Early identification Electronic medical records
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ISSN	0162-3257 1573-3432 1573-3432
DOI	10.1007/s10803-021-05380-3

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Summary:	In autism spectrum disorder (ASD), medical conditions in infancy could be predictive markers for later ASD diagnosis. In this study, electronic medical records of 579 autistic individuals and 1897 matched controls prior to age 2 were analyzed for potential predictive conditions. Using a novel tool, the relative association of each condition in the autistic group was compared to the control group using logistic regressions across medical records. Generalized convulsive epilepsy, nystagmus, lack of normal physiological development, delayed milestones, and strabismus were more likely in those later diagnosed with ASD while perinatal jaundice was less likely to be associated. Lesser-known conditions, such as strabismus and nystagmus, may point to novel predictive co-occurring condition profiles which could improve screening practices for ASD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Zachary J. Williams assisted in data analysis and interpretation, figure creation, and drafting/revising the manuscript. Kyle L. Schwartz assisted in drafting the initial manuscript and reviewed and revised the manuscript. Michelle D. Failla designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. Laurie E. Cutting, Bennett A. Landman, and Carissa J. Cascio conceptualized and designed the study, coordinated and supervised data analysis, and reviewed and revised the manuscript. Ekomobong E. Eyoh performed initial and revised data analysis and interpretation, drafted the manuscript, created figures and tables, and reviewed and revised the final manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. Contributors’ Statement
ISSN:	0162-3257 1573-3432 1573-3432
DOI:	10.1007/s10803-021-05380-3