Two Human Infections with Diverse Europe-1 Crimean-Congo Hemorrhagic Fever Virus Strains, North Macedonia, 2024

• Published in: Emerging infectious diseases Vol. 31; no. 2; pp. 313 - 317
• Main Authors: Jakimovski, Dejan, Poposki, Kostadin, Dimzova, Marija, Cvetanovska, Marija, Cana, Fadil, Bogdan, Ivana, Cabezas-Cruz, Alejandro, Zana, Brigitta, Lanszki, Zsófia, Tauber, Zsófia, Görföl, Tamás, Bányai, Krisztián, Ábrahám, Ágota, Banović, Pavle, Kemenesi, Gábor
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.02.2025; Centers for Disease Control and Prevention
• Subjects: Abdomen; Analysis; Balkan; Case studies; Causes of; CCHFV; Crimean hemorrhagic fever; Crimean-Congo hemorrhagic fever; Dispatch; Epidemics; Female; Fever; Health aspects; Hemorrhagic fever; Hemorrhagic Fever Virus, Crimean-Congo - classification; Hemorrhagic Fever Virus, Crimean-Congo - genetics; Hemorrhagic Fever Virus, Crimean-Congo - isolation & purification; Hemorrhagic Fever, Crimean - diagnosis; Hemorrhagic Fever, Crimean - epidemiology; Hemorrhagic Fever, Crimean - virology; Humans; Infections; Infectious diseases; Life Sciences; Male; Medical history; Microbiology and Parasitology; Middle Aged; North Macedonia; Pathogens; Patients; phylogenetic analysis; Phylogenetics; Phylogeny; Public health; Republic of North Macedonia - epidemiology; Software; Thrombocytopenia; Two Human Infections with Diverse Europe-1 Crimean-Congo Hemorrhagic Fever Virus Strains, North Macedonia, 2024; Vectors (Biology); viruses; Zoonoses; Republic of North Macedonia; Congo (Kinshasa); North Macedonia; Europe; Ukraine; Turkey; Kosovo; Asia; Africa; Balkan; phylogenetic analysis; viruses; vector-borne infections; ticks; CCHFV; North Macedonia; tickborne; zoonoses; Crimean-Congo hemorrhagic fever
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid3102.241249

Until 2023, North Macedonia had not reported a Crimean-Congo hemorrhagic fever (CCHF) case for >50 years. In 2024, increased clinical vigilance identified and characterized 2 novel CCHF cases. Genetic analysis and the identification of possible reassortment indicate North Macedonia as an interaction zone between CCHF virus isolates from Turkey and Kosovo.