Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

• Published in: Lipids in health and disease Vol. 19; no. 1; pp. 113 - 15
• Main Authors: Kolczynska, Katarzyna, Loza-Valdes, Angel, Hawro, Izabela, Sumara, Grzegorz
• Format: Journal Article
• Language: English
• Published: London BioMed Central 28.05.2020; BioMed Central Ltd; BMC
• Subjects: Animals; Apoptosis; Binding sites; Biomedical and Life Sciences; Biosynthesis; Clinical Nutrition; Development and progression; Diabetes mellitus; Diabetes Mellitus - etiology; Diabetes Mellitus - metabolism; Diabetes therapy; Diacylglycerol (DAG); Diglycerides; Diglycerides - metabolism; Enzymes; Fatty acids; Glucose; Glucose - metabolism; Homeostasis; Humans; Insulin; Insulin - metabolism; Insulin resistance; Insulin signaling; Isoforms; Kinases; Life Sciences; Lipid Metabolism; Lipidology; Lipids; Lipids as signaling molecules; Medical Biochemistry; Medical research; Membranes; Metabolic disorders; Metabolism; Obesity; Obesity - etiology; Obesity - metabolism; Pathogenesis; Physiological aspects; PKC; PKD; Plasma; Protein kinase C; Protein Kinase C - metabolism; Protein kinases; Protein turnover; Proteins; Regulation; Review; Signal Transduction; Type 2 diabetes; PKD; PKC; Diacylglycerol (DAG); Metabolism; Insulin signaling
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-020-01286-8

Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes.