Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients

• Published in: Intensive care medicine Vol. 41; no. 5; pp. 833 - 845
• Main Authors: Krag, Mette, Perner, Anders, Wetterslev, Jørn, Wise, Matt P., Borthwick, Mark, Bendel, Stepani, McArthur, Colin, Cook, Deborah, Nielsen, Niklas, Pelosi, Paolo, Keus, Frederik, Guttormsen, Anne Berit, Moller, Alma D., Møller, Morten Hylander
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2015; Springer; Springer Nature B.V
• Subjects: Acids; Acute Disease; Adult; Adults; Aged; Analysis; Anestesi och intensivvård; Anesthesiology; Anesthesiology and Intensive Care; Clinical Medicine; Confounding Factors (Epidemiology); Critical care; Critical Care Medicine; Denmark; Disease prevention; Emergency Medicine; Female; Gastroenterologi och hepatologi; Gastroenterology and Hepatology; Gastrointestinal Hemorrhage - diagnosis; Gastrointestinal Hemorrhage - epidemiology; Gastrointestinal Hemorrhage - etiology; Hospital patients; Hospitals; Humans; Intensive; Intensive care; Intensive Care Units; Klinisk medicin; Liver diseases; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Middle Aged; Mortality; Original; Pain Medicine; Patient outcomes; Pediatrics; Pneumology/Respiratory System; Prevalence; Prognosis; Proton Pump Inhibitors - adverse effects; Proton Pump Inhibitors - therapeutic use; Risk Factors; Stomach Ulcer - drug therapy; Ulcers; Denmark; United Kingdom > UK; Sweden; Proton pump inhibitors; Histamine-2 receptor antagonists; Intensive care; Stress ulcer prophylaxis; Gastrointestinal bleeding; Critically ill patients
• ISSN: 0342-4642; 1432-1238; 1432-1238
• DOI: 10.1007/s00134-015-3725-1

Purpose To describe the prevalence of, risk factors for, and prognostic importance of gastrointestinal (GI) bleeding and use of acid suppressants in acutely ill adult intensive care patients. Methods We included adults without GI bleeding who were acutely admitted to the intensive care unit (ICU) during a 7-day period. The primary outcome was clinically important GI bleeding in ICU, and the analyses included estimations of baseline risk factors and potential associations with 90-day mortality. Results A total of 1,034 patients in 97 ICUs in 11 countries were included. Clinically important GI bleeding occurred in 2.6 % (95 % confidence interval 1.6–3.6 %) of patients. The following variables at ICU admission were independently associated with clinically important GI bleeding: three or more co-existing diseases (odds ratio 8.9, 2.7–28.8), co-existing liver disease (7.6, 3.3–17.6), use of renal replacement therapy (6.9, 2.7–17.5), co-existing coagulopathy (5.2, 2.3–11.8), acute coagulopathy (4.2, 1.7–10.2), use of acid suppressants (3.6, 1.3–10.2) and higher organ failure score (1.4, 1.2–1.5). In ICU, 73 % (71–76 %) of patients received acid suppressants; most received proton pump inhibitors. In patients with clinically important GI bleeding, crude and adjusted odds for mortality were 3.7 (1.7–8.0) and 1.7 (0.7–4.3), respectively. Conclusions In ICU patients clinically important GI bleeding is rare, and acid suppressants are frequently used. Co-existing diseases, liver failure, coagulopathy and organ failures are the main risk factors for GI bleeding. Clinically important GI bleeding was not associated with increased adjusted 90-day mortality, which largely can be explained by severity of comorbidity, other organ failures and age.