Therapeutic role of mesenchymal stem cells (MSCs) in diabetic kidney disease (DKD)

Findings of preclinical studies and recent phase I/II clinical trials have shown that mesenchymal stem cells (MSCs) play a significant role in the development of diabetic kidney disease (DKD). Thus, MSCs have attracted increasing attention as a novel regenerative therapy for kidney diseases. This re...

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Bibliographic Details
Published inENDOCRINE JOURNAL Vol. 69; no. 10; pp. 1159 - 1172
Main Authors Liu, Jie, Li, Xiangling, Xu, Ning
Format Journal Article
LanguageEnglish
Published Kyoto The Japan Endocrine Society 01.01.2022
Japan Science and Technology Agency
Subjects
Angiogenesis
Clinical trials
Diabetes mellitus
Diabetic kidney disease
Fibrosis
Hyperglycemia
Kidney diseases
Mesenchymal stem cells
Renal function
Stem cells
Therapy
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ISSN0918-8959
1348-4540
1348-4540
DOI10.1507/endocrj.EJ22-0123

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Summary:Findings of preclinical studies and recent phase I/II clinical trials have shown that mesenchymal stem cells (MSCs) play a significant role in the development of diabetic kidney disease (DKD). Thus, MSCs have attracted increasing attention as a novel regenerative therapy for kidney diseases. This review summarizes recent literature on the roles and potential mechanisms, including hyperglycemia regulation, anti-inflammation, anti-fibrosis, pro-angiogenesis, and renal function protection, of MSC-based treatment methods for DKD. This review provides novel insights into understanding the pathogenesis of DKD and guiding the development of biological therapies.
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ISSN:0918-8959
1348-4540
1348-4540
DOI:10.1507/endocrj.EJ22-0123