Werner Syndrome and Diabetes Mellitus Accompanied by Adrenal Cortex Cancer

• Published in: Internal Medicine Vol. 56; no. 15; pp. 1987 - 1992
• Main Authors: Sanada, Junpei, Nakanishi, Shuhei, Shimoda, Masashi, Irie, Shintaro, Hirukawa, Hidenori, Fushimi, Yoshiro, Tatsumi, Fuminori, Kohara, Kenji, Obata, Atsushi, Hirata, Yurie, Kimura, Tomohiko, Tanabe, Akihito, Mune, Tomoatsu, Kamei, Shinji, Kaneto, Hideaki, Kinoshita, Tomoe, Nishioka, Momoyo, Kaku, Kohei
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2017; Japan Science and Technology Agency
• Subjects: adrenal cancer; Adrenal cortex; Adrenal Cortex Neoplasms - complications; Adrenal glands; Adrenocorticotropic hormone; Cancer; Case Report; Cataracts; Computed tomography; Cushing syndrome; Cushing Syndrome - complications; Diabetes; Diabetes Complications - epidemiology; Diabetes mellitus; Female; Humans; Internal medicine; Magnetic Resonance Imaging; Malignancy; Middle Aged; Nervous system diseases; Neuroimaging; Pituitary; Progeria; Radionuclide Imaging; Scintigraphy; Tomography, X-Ray Computed; Werner syndrome; Werner Syndrome - complications; Werner's syndrome; adrenal cancer; diabetes mellitus; Werner syndrome
• ISSN: 0918-2918; 1349-7235; 1349-7235
• DOI: 10.2169/internalmedicine.56.8231

Werner syndrome is a rare genetic disease characterized by progeria, diabetes mellitus, cataracts and various types of malignancy. However, there are few reports showing adrenal cortex cancer in subjects with Werner syndrome. We herein report an extremely rare case of Werner syndrome accompanied by adrenal cortex cancer. Based on the data obtained from blood samples, computed tomography, magnetic resonance imaging and 131I adosterol scintigraphy, we diagnosed this subject with adrenal cortex cancer and Cushing's syndrome. Since the prognosis of adrenal cancer is very poor, we should be aware of the possibility of adrenal cancer occurring in subjects with Werner syndrome.