Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: A report from the Cardiothoracic Surgical Trials Network

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 143; no. 1; pp. 111 - 117.e1
• Main Authors: Smith, Peter K., Michler, Robert E., Woo, Y. Joseph, Alexander, John H., Puskas, John D., Parides, Michael K., Hahn, Rebecca T., Williams, Judson B., Dent, John M., Ferguson, T. Bruce, Moquete, Ellen, Rose, Eric A., Pagé, Pierre, Jeffries, Neal O., O’Gara, Patrick T., Ascheim, Deborah D.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.01.2012; Elsevier
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cardiology. Vascular system; Cardiothoracic Surgery; Coronary Artery Disease - complications; Endocardial and cardiac valvular diseases; Heart; Humans; Medical sciences; Mitral Valve Insufficiency - complications; Mitral Valve Insufficiency - surgery; Pneumology; Prospective Studies; Severity of Illness Index; 35; CTSN; ERO; NHLBI; TTE; TEE; LVESVI; CABG; IMR; effective regurgitant orifice; left ventricular end-systolic volume index; National Heart, Lung, and Blood Institute; transthoracic echocardiography; Cardiothoracic Surgical Trials Network; ischemic mitral regurgitation; transesophageal echocardiography; coronary artery bypass grafting; Mitral valve; Cardiovascular disease; Design; Treatment; Ischemia; Cardiac valvular disease; Surgery; Network; Mitral regurgitation; Anesthesia; Circulatory system; Cardiology; Initiation
• ISSN: 0022-5223; 1097-685X; 1097-685X
• DOI: 10.1016/j.jtcvs.2011.05.006

Patients with coronary artery disease complicated by moderate ischemic mitral regurgitation have demonstrably poorer outcome than do patients with coronary artery disease but without mitral regurgitation. The optimal treatment of this condition has become increasingly controversial, and a randomized trial evaluating current practices is warranted. We describe the design and initial execution of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial. This is an ongoing prospective, multicenter, randomized, controlled clinical trial designed to test the safety and efficacy of mitral repair in addition to coronary artery bypass grafting in the treatment of moderate ischemic mitral regurgitation. The results of the Cardiothoracic Surgical Trials Network Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial will provide long-awaited information on controversial therapies for this morbid disease process.