盐霉素诱导的细胞自噬机制在抗癌治疗中的应用进展
自噬在肿瘤的发生、发展、治疗过程中扮演着重要的角色。盐霉素作为一种聚醚类离子载体型抗生素，一直被用于防治鸡球虫病和促进反刍动物生长；它也能有效杀伤多种肿瘤干细胞及多药耐药肿瘤细胞系，且在此过程中伴随自噬的发生。盐霉素诱导的自噬是复杂的，可由细胞内活性氧升高而激活自噬；可通过损伤线粒体引发线粒体自噬；可引起内质网应激，通过 AKT1-mTOR信号通路激活自噬。此外，盐霉素可抑制自噬潮的晚期阶段，有助于肿瘤微环境的破坏和自身抗肿瘤作用的提高。本文综述了盐霉素在禽畜疾病中的应用及机制、盐霉素抗肿瘤的作用机制及盐霉素诱导自噬的机制。...
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| Published in | 浙江大学学报（农业与生命科学版） Vol. 42; no. 6; pp. 694 - 702 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
浙江大学医学院附属口腔医院，病理科，杭州 310006
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-9209 |
| DOI | 10.3785/j.issn.1008-9209.2016.07.123 |
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| Summary: | 自噬在肿瘤的发生、发展、治疗过程中扮演着重要的角色。盐霉素作为一种聚醚类离子载体型抗生素，一直被用于防治鸡球虫病和促进反刍动物生长；它也能有效杀伤多种肿瘤干细胞及多药耐药肿瘤细胞系，且在此过程中伴随自噬的发生。盐霉素诱导的自噬是复杂的，可由细胞内活性氧升高而激活自噬；可通过损伤线粒体引发线粒体自噬；可引起内质网应激，通过 AKT1-mTOR信号通路激活自噬。此外，盐霉素可抑制自噬潮的晚期阶段，有助于肿瘤微环境的破坏和自身抗肿瘤作用的提高。本文综述了盐霉素在禽畜疾病中的应用及机制、盐霉素抗肿瘤的作用机制及盐霉素诱导自噬的机制。 |
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| Bibliography: | Summary Autophagy is a cell self-eating process that allows the orderly degradation and recycling of misfolded proteins and damaged organelles through lysosome.It plays a vital role in cells”adaptation to metabolic stress and homeostasis as well as the formation,development and treatment of tumors.Autophagy is a double-edged sword, both suppressing and facilitating tumorigenesis.For example,multiple benign tumors formed in the liver when autophagy gene Atg5 was mosaically deleted in mice.But at the same time,cancer cells can upregulate autophagy to survive under microenvironmental stress, promote tumor dormancy and increase their growth and aggressiveness. Salinomycin is a polyether ionophore antibiotic isolated from Streptomycesalbus.Compared with lasalocid and monensin,salinomycin is less toxic,lower priced and less susceptible to drug resistance,which enables worldwide use to prevent chicken coccidiosis and promote the growth of ruminants.As an antimicrobial drug,salinomycin acts as an ionophore for K＋ and |
| ISSN: | 1008-9209 |
| DOI: | 10.3785/j.issn.1008-9209.2016.07.123 |