Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5‐generated cyclic adenosine monophosphate
Epidemiological and functional studies show that impaired arterial myocyte contractility contributes to vascular complications in diabetes patients and animal models of diabetes . [...]to clarify the mechanism of how hyperglycemia increases vascular tone is an important subject of diabetes research....
Saved in:
| Published in | Journal of diabetes investigation Vol. 11; no. 4; pp. 783 - 785 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
John Wiley & Sons, Inc
01.07.2020
John Wiley and Sons Inc Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2040-1116 2040-1124 2040-1124 |
| DOI | 10.1111/jdi.13186 |
Cover
| Abstract | Epidemiological and functional studies show that impaired arterial myocyte contractility contributes to vascular complications in diabetes patients and animal models of diabetes . [...]to clarify the mechanism of how hyperglycemia increases vascular tone is an important subject of diabetes research. Because AC6 is not close to the CaV1.2 in the previous report, this intimate spatial organization might be an important role for local PKA‐dependent regulation of L‐type Ca2+ channels in arterial myocytes. [...]the authors analyzed the function of AC5 in diabetes model mice. [...]the discrepancy of canonical function of PKA is still unknown. |
|---|---|
| AbstractList | Epidemiological and functional studies show that impaired arterial myocyte contractility contributes to vascular complications in diabetes patients and animal models of diabetes . [...]to clarify the mechanism of how hyperglycemia increases vascular tone is an important subject of diabetes research. Because AC6 is not close to the CaV1.2 in the previous report, this intimate spatial organization might be an important role for local PKA‐dependent regulation of L‐type Ca2+ channels in arterial myocytes. [...]the authors analyzed the function of AC5 in diabetes model mice. [...]the discrepancy of canonical function of PKA is still unknown. |
| Author | Yokote, Koutaro Sakamoto, Kenichi |
| AuthorAffiliation | 1 Department of Endocrinology, Hematology, and Gerontology Chiba University Graduate School of Medicine Chiba Japan 2 Department of Medicine, Diabetes, Obesity and Metabolism Institute (DOMI) Icahn School of Medicine at Mt Sinai New York City New York USA 3 Division of Diabetes, Metabolism and Endocrinology Chiba University Hospital Chiba Japan |
| AuthorAffiliation_xml | – name: 2 Department of Medicine, Diabetes, Obesity and Metabolism Institute (DOMI) Icahn School of Medicine at Mt Sinai New York City New York USA – name: 3 Division of Diabetes, Metabolism and Endocrinology Chiba University Hospital Chiba Japan – name: 1 Department of Endocrinology, Hematology, and Gerontology Chiba University Graduate School of Medicine Chiba Japan |
| Author_xml | – sequence: 1 givenname: Kenichi orcidid: 0000-0002-7878-5763 surname: Sakamoto fullname: Sakamoto, Kenichi email: ksakamoto-cib@umin.ac.jp organization: Icahn School of Medicine at Mt Sinai – sequence: 2 givenname: Koutaro surname: Yokote fullname: Yokote, Koutaro email: kyokote@faculty.chiba-u.jp organization: Chiba University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31758873$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1u1DAQxyNUREvpgRdAlrgA0rZxPpzkgoTK16IKLnC2JpPJxivHXuxkq9x4BJ6CB-NJ8GbLilaivtia-c1_xjPzODoy1lAUPeXxOQ_nYt2oc57yUjyITpI4ixecJ9nR4c3FcXTm_ToOJy1LIYpH0XHKi7wsi_Qk-vXZbkmznrADo3zPbMuUQUfglVkxJEe1A8224HHU4Bha4wencFDWBJIBjgOxbtqQW-kJqVfAwDSsUVDTQJ4NnbPjqmPQkJn0pBlOqMETy3__-LkiQw4GamarwpmyITWx3hq76azfdMH_JHrYgvZ0dnOfRt_ev_t6-XFx9eXD8vLN1QJFnosFVnFKVdui4BkRFiLnSQ5VjSLJsrjkyGPIkipOmpygbjOooIa8yTNRUVthm55Gy71uY2EtN0714CZpQcnZYN1KghsUapJNUVVUtElaEGZlUdSI1S5_BoRJE_Og9WqvNZoNTNeg9UGQx3I3OxlmJ-fZBfj1Ht6MdU8NkhlC229VcNtjVCdXdiuLtCizNA4CL24EnP0-kh9krzyS1mDIjl4m88xFNaPP76BrOzoT-ipDm0rBizip7qcSkaW7BQvUs3_rPhT8d8MC8HIPoLPeO2rvbcLFHRbVALtNC19W-r6Ia6Vp-r-0_PR2uY_4AzcJBTo |
| CitedBy_id | crossref_primary_10_14336_AD_2023_0823_4 |
| Cites_doi | 10.1172/JCI124705 10.1002/cphy.c160011 10.1007/s00125-013-2974-1 10.1126/scisignal.aaf9647 10.7554/eLife.42214 |
| ContentType | Journal Article |
| Copyright | 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd 2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd – notice: 2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T5 7TM 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH H94 K9. M0S PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1111/jdi.13186 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Nucleic Acids Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts Immunology Abstracts ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 6 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Sakamoto and Yokote |
| EISSN | 2040-1124 |
| EndPage | 785 |
| ExternalDocumentID | oai_doaj_org_article_d799e7f237ec4877bcc9c9034aec2d01 10.1111/jdi.13186 PMC7378430 31758873 10_1111_jdi_13186 JDI13186 |
| Genre | commentary Journal Article Commentary |
| GroupedDBID | --- 05W 0R~ 1OC 24P 31~ 4.4 50Y 5DZ 5VS 7X7 8-0 8-1 8FI 8FJ AAHHS AANHP AAZKR ABDBF ABJNI ABUWG ACBWZ ACCFJ ACCMX ACGFO ACPRK ACRPL ACUHS ACXQS ACYXJ ADBBV ADKYN ADNMO ADPDF ADRAZ ADZMN AEEZP AEGXH AENEX AEQDE AFKRA AHMBA AIAGR AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS ASPBG AVUZU AVWKF AZFZN BAWUL BCNDV BDRZF BENPR BPHCQ BVXVI CAG CCPQU COF DIK EBD EBS EJD FYUFA GODZA GROUPED_DOAJ GX1 HMCUK HYE HZ~ KQ8 LH4 LW6 M48 MY. O9- OK1 OVD PIMPY PQQKQ PROAC RPM RX1 SUPJJ TEORI UKHRP WIN AAMMB AAYXX AEFGJ AGQPQ AGXDD AIDQK AIDYY CITATION PHGZM PHGZT PUEGO CGR CUY CVF ECM EIF NPM 3V. 7T5 7TM 7XB 8FK AZQEC DWQXO H94 K9. PKEHL PQEST PQUKI PRINS 7X8 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c6556-c903e9ffc614eec765125a9bc6244081c10a42902d5eabf4a9aba5d5469ef9cf3 |
| IEDL.DBID | M48 |
| ISSN | 2040-1116 2040-1124 |
| IngestDate | Wed Aug 27 01:26:53 EDT 2025 Wed Aug 20 00:10:20 EDT 2025 Tue Sep 30 16:59:45 EDT 2025 Fri Sep 05 14:57:16 EDT 2025 Fri Jul 25 08:10:32 EDT 2025 Mon Jul 14 10:40:33 EDT 2025 Mon Jul 21 05:58:22 EDT 2025 Thu Apr 24 23:03:56 EDT 2025 Wed Oct 01 03:30:51 EDT 2025 Wed Jan 22 16:32:49 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Attribution-NonCommercial This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. cc-by-nc |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c6556-c903e9ffc614eec765125a9bc6244081c10a42902d5eabf4a9aba5d5469ef9cf3 |
| Notes | SourceType-Scholarly Journals-1 ObjectType-Commentary-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-7878-5763 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1111/jdi.13186 |
| PMID | 31758873 |
| PQID | 2426432040 |
| PQPubID | 1006415 |
| PageCount | 3 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_d799e7f237ec4877bcc9c9034aec2d01 unpaywall_primary_10_1111_jdi_13186 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7378430 proquest_miscellaneous_2317586930 proquest_journals_2448617029 proquest_journals_2426432040 pubmed_primary_31758873 crossref_primary_10_1111_jdi_13186 crossref_citationtrail_10_1111_jdi_13186 wiley_primary_10_1111_jdi_13186_JDI13186 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | July 2020 |
| PublicationDateYYYYMMDD | 2020-07-01 |
| PublicationDate_xml | – month: 07 year: 2020 text: July 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan – name: Richmond – name: Hoboken |
| PublicationTitle | Journal of diabetes investigation |
| PublicationTitleAlternate | J Diabetes Investig |
| PublicationYear | 2020 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2019; 8 2017; 7 2013; 56 2017; 10 2019; 129 e_1_2_3_2_1 e_1_2_3_6_1 e_1_2_3_5_1 e_1_2_3_4_1 e_1_2_3_3_1 |
| References_xml | – volume: 7 start-page: 485 year: 2017 end-page: 581 article-title: Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles publication-title: Compr Physiol – volume: 10 year: 2017 article-title: Ser1928 phosphorylation by PKA stimulates the L‐type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes publication-title: Sci Signal – volume: 8 year: 2019 article-title: A Gs‐coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia publication-title: eLife – volume: 129 start-page: 3140 year: 2019 end-page: 3152 article-title: Adenylyl cyclase 5‐generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia publication-title: J Clin Investig – volume: 56 start-page: 2122 year: 2013 end-page: 2133 article-title: Vascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta‐analysis publication-title: Diabetologia – ident: e_1_2_3_4_1 doi: 10.1172/JCI124705 – ident: e_1_2_3_6_1 doi: 10.1002/cphy.c160011 – ident: e_1_2_3_2_1 doi: 10.1007/s00125-013-2974-1 – ident: e_1_2_3_3_1 doi: 10.1126/scisignal.aaf9647 – ident: e_1_2_3_5_1 doi: 10.7554/eLife.42214 |
| SSID | ssj0000388667 |
| Score | 2.1907732 |
| Snippet | Epidemiological and functional studies show that impaired arterial myocyte contractility contributes to vascular complications in diabetes patients and animal... |
| SourceID | doaj unpaywall pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 783 |
| SubjectTerms | Acute Disease Adenosine triphosphate Adenylate cyclase Adenylyl Cyclases - metabolism Animal models Calcium channels Calcium channels (voltage-gated) Cerebrovascular Circulation - physiology Commentaries Constriction Contractility Cyclic AMP Cyclic AMP - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Epidemiology Glucose Humans Hyperglycemia Hyperglycemia - etiology Hyperglycemia - physiopathology Hypertension Kinases Myocytes Pathophysiology Protein kinase A Proteins Veins & arteries |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LbtQwFLVQF8AG8SalIPNYdBNI4veyPKpSqV1RqbvIcexOpEwymgcoOz6Br-DD-JJeO5moES1s2I1yr6KJfex7bF-fi9BbASBRXMPsR0sSU4hxsS45i51OpaNUyzRUiTg55Udn9PicnV8p9eVzwnp54L7h3pdCKStcRoQ1QK5FYYwyKiFUW5OV_c0tCGNXFlNhDiZS8lA-NvMpczCg-SArFNJ4yupdCmDmk2AUNPuvI5p_5kve2TQL3X3XdT3ltCEoHd5H9wY2iQ_6r3iAbtnmIbp9MpyXP0K_TttvtsZz6-_3Vqs5bh2uGk8U_RYBNnbpz41rvM1HxcbTxWUVLjuAJ9Zms7Z4BovV5UXdGTuvNNZNibdbtnio84M1zF9d3dXYdAYIucXs94-fF0HTGjhteFqZ4NX6THsM6G8Xs3a1mIH9MTo7_Pz141E8VGaIDWeMx74DrHLOQHC31ggOtIFpVRie-QrWqUkTDYEuyUpmdeGoVrrQrGSwFrdOGUeeoJ2mbewzhJnIEiFIAa9NKDRxoQVxkhaE88RSySK0v-2i3Ayy5b56Rp2Py5eyykNvRuj16LrotTquc_rg-3l08PLa4QGALh9Al_8LdBHa26IkH8b8Kg_kkni83WCm0qvfZypCr0YzDGZ_QqMb227Ax7M56atTRuhpj7nxjwaTFCRCYoLGyZdMLU01C4LhgghJ_TvfjLj9WwPtB0Tf7JEff_oSfuz-j7Z8ju5mfg8jpEDvoZ31cmNfANFbFy_DmL4EuaNTlQ priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagSMAF8SZQkHkcegnk4UdyQryqUqk9UWlvkeM4u5GySZrdLcqNn8Cv4IfxS5jxOpFWtL2tMqNobX_j-TyezBDyTgJIUqFg92NF7DPwcb4qBPdLFSYlYyoJbZeIk1NxdMaOZ3zmAm4rl1Y57ol2oy5ajTHyD-CGEiweHqUfu3Mfu0bh7aproXGT3AqBqiCq5UxOMRasdCJsE9kIE-fArIUrLmSTeYrqfQiQFjsuyVbuv4xu_p81eWfTdGr4qep6l9la13R4n9xznJJ-2oLgAblhmofk9om7NX9E_py2F6amS4Nf-VarJW1LWjVIFzFQQLXp8fa4pmNWKtVIGvvKfvIAmlTpzdrQBRxZ-3k9aLOsFFVNQcfALXXdfqiCXWyoh5rqQQMtN5T__fV7bitbA7O1TytttVrMt6cwqW23aFfdAuSPydnhtx9fjnzXn8HXgnPh6zSITVqWGly8MVoKIA9cpbkWEfaxDnUYKHB3QVRwo_KSqVTlihccTuSmTHUZPyF7TduYZ4RyGQVSxjm8NmAwxbmScZmwPBYiMCzhHjkYlyjTrng59tCos-kQU1SZXU2PvJlUu23FjsuUPuM6TwpYZNs-aPt55mw2K2SaGllGsTQaznUy1zrFMTNldFQEoUf2R5RkzvJXmaWYMeLtCvEIY4-8nsRg0nhPoxrTbkAHOV2CPSo98nSLuemPWlEiY4_IHTTujGRX0lQLWzZcxjJh-M63E26vm6ADi-irNbLjr9_tj-fXj_MFuRthjMKmOO-TvXW_MS-ByK3zV9Za_wE58kqC priority: 102 providerName: ProQuest – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LbtQwFLVgKkE3vKGBgsxj0U2GPOw4WZZHVSp1xIKRyio4jj0TkUlG8wANKz6Br-DD-BLudTJBgRYhsYviGytOjq-P7etzCXkmACRJJMH7sTx0GYxxrswj7hrpx4YxGfs2S8TpKDoes5MzftbmOcWzMI0-RLfghj3D-mvs4PPcNH7-eRePkxdDH1AZXSY7Ee4wDcjOePT28D2mlMNYOTCKfl0HrNUW6j3bG5GscP95bPPPoMmr62ouN59lWfaJrR2Zjq6TD9s2NQEpH4frVTZUX36Te_yPRt8g11rWSg8bmN0kl3R1i1w5bfflb5Pvo_qTLulM4zniYjmjtaFFhYQUlyKo0gvcny7pNu6VKqSli8IeqgBLKtV6pekUJsWLSblRelZIKqucbpeGaZtPiErwk5tyU1K1UUD8NeU_vn6bWO1s4M72bqGsVY0R_RR6WT2f1sv5FMrvkPHR63cvj902A4SrIs4jVyVeqBNjFJAIrZWIgJ5wmWQqCjBTtq98T8KA6gU51zIzTCYykzznMOfXJlEmvEsGVV3pPUK5CDwhwgyq9Rj8xUyK0MQsCwE3msXcIQdbFKSqlUfHLB1l2k2T8iK1390hTzrTeaMJcp7RC4RSZ4Ay3vZGvZikrVdIc5EkWpggFFrBzFFkSiXYZia1CnLPd8j-Fohp61uWqSWxIUL6gmIWo8p-kDjkcVcMTgN3gmSl6zXYIGuMMQumQ-41sO5e1BbFInSI6AG-15J-SVVMrTC5CEXMsM6nXdf42wc6sEi_2CI9efXGXtz_pwofkN0AF0NsLPU-GawWa_0QGOMqe9R6hZ_mnG41 priority: 102 providerName: Unpaywall – databaseName: Wiley Online Library Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZKkYBLxbOkFGQeh16C8vAjESdeVanUigOVeoscx96NlE1W2V1QbvwEfgU_jF_CjDeJiGgRt1VmEm3iGc_n8fgbQl5JMJJUKJj9WBH7DGKcrwrBfavCxDKmktB1iTg7FycX7PSSX-6QN8NZmC0_xJhwQ89w8zU6uMpXfzp5Ub4OwSLFDXIzxKiPtM7s85hgQZoT4TrIRlg1BzeJnlnIVfIMd0_ikaPtvwpr_l0yeXtTL1X3TVXVFNa6uHR8l-z1gJK-3VrAPbJj6vvk1lm_Zf6A_DxvvpqKLgwe8S1XC9pYWtaIFTFLQLVpceu4okNJKtWIGNvSnXcATar0Zm3oHNar7azqtFmUiqq6oEPWlvatfqiCKayruorqTgMmN5T_-v5j5mitAda6q6V2Wg0W21NwgGY5b1bLOcgfkovjj1_en_h9cwZfC86Fr9MgNqm1GuK7MVoKQA5cpbkWETaxDnUYKIh1QVRwo3LLVKpyxQsOy3FjU23jR2S3bmrzmFAuo0DKOIfHBgw-ca5kbBOWx0IEhiXcI0fDEGW6Zy7HBhpVNq5gijJzo-mRF6PqckvXcZXSOxznUQEZtt2Fpp1lvcNmhUxTI20US6NhUSdzrVN8Z6aMjoog9MjhYCVZ7_arzOHLGO3tGjFLkAA_Sj3yfBSDP-MmjapNswEdBHQJNqj0yP7W5sY_6kSJjD0iJ9Y4eZOppC7njjNcxjJh-MyXo93-6wMdOYu-XiM7_fDJ_Tj4f9Un5E6EyQpX63xIdtftxjwFRLfOnznP_Q1YJUp0 priority: 102 providerName: Wiley-Blackwell |
| Title | Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5‐generated cyclic adenosine monophosphate |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjdi.13186 https://www.ncbi.nlm.nih.gov/pubmed/31758873 https://www.proquest.com/docview/2426432040 https://www.proquest.com/docview/2448617029 https://www.proquest.com/docview/2317586930 https://pubmed.ncbi.nlm.nih.gov/PMC7378430 https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.13186 https://doaj.org/article/d799e7f237ec4877bcc9c9034aec2d01 |
| UnpaywallVersion | publishedVersion |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: KQ8 dateStart: 20140101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: KQ8 dateStart: 20100101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: ABDBF dateStart: 20120401 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: DIK dateStart: 20100101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: RPM dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: 7X7 dateStart: 20140101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: BENPR dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2040-1124 dateEnd: 20250630 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: M48 dateStart: 20100501 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal – providerCode: PRVWIB databaseName: KBPluse Wiley Online Library: Open Access customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: AVUZU dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.kbplus.ac.uk/kbplus7/publicExport/pkg/559 providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 2040-1124 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000388667 issn: 2040-1116 databaseCode: 24P dateStart: 20100101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NjtMwELb2R1r2gvhdAktlfg57ySqJHTs5ILQLu1pWalUhKi2nyHGcNlKalLQFcuMReAoejCdh7CaRIrocuFSVPYkS-xvPN_ZkBqHXHEASMgGrH02ITcHG2SJhvp0KN0gpFYFrqkQMR-xqQq9v_Jsd1NbYbAZwudW10_WkJlV--v1L_RYU_k0XlZNkpy5gk-2ifTBIngb3sGH5ZkEmQcBMLVlPx8_BJazJMdS7-hAdaGMKWkd6Rsrk8t9GQP-Oo7yzLhai_ibyvM91jbG6vIfuNiwTn21gcR_tqOIBOhg25-gP0a9R-VXleK70d7_Zco7LFGeFJpB66wBLVenz5By3capYahpZZeYjCJDEQq5XCs_Aia2meS3VPBNYFAlut3JxU_8HC1jX6rzOsawlEHWF_d8_fk5NrmvguqY1k0aq1BH4GLSiXMzK5WIG_Y_Q5PLi07sru6nYYEvm-8yWoUNUmKYSjL5SkjOgE74IY8k8Xdnala4jwAA6XuIrEadUhCIWfuKDj67SUKbkMdorykI9QdjnnsM5ieG2DoUhjgUnaUBjwpijaOBb6KSdokg26cx1VY086tyaJIvMxFroZSe62OTw2CZ0rue5E9Bpt01DWU2jRoujhIeh4qlHuJLg6fFYylC_MxVKeonjWui4RUnUQjkypJNo6N3STQOdFd8LLfSi6wYl1yc3olDlGmQMMHXVSgsdbTDXPWiLWQvxHhp7b9LvKbKZSSTOCQ-ovuerDrf_GqATg-jbJaLr9x_Mn6f__SjP0KGnNzRMPPQx2ltVa_UcWN8qHqBdj47hl9_wAdo_vxiNPw7MDsrAaDu0TUbjs89_ADQkX5E |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKkSgXxJtAAfOSegnk4djJASGgVLttd0-ttLfUcZzdSNlk2QdVbvwEfgVHfhS_hBlvEmlF21tvUTyy4sx4Xh7PR8hbAUIScQnaj6W-zcDG2TLlgZ1JN8wYk6FrUCIGQ947ZYejYLRF_rR3YbCsstWJRlGnlcIc-QcwQyE2D_eiT7PvNqJG4elqC6GxFosjXZ9DyLb42N8H_r7zvINvJ197doMqYCseBNxWkePrKMsUGCatleBg8gIZJYp7iL7sKteRoKQdLw20TDImI5nIIA0gjtRZpDIf5r1BbjLfYdirX4xEl9PBzircgNZ6WKgHaoQ3zYxM8VCav3dhC_ENE2iQAi5yb_-v0txZlTNZn8ui2PSkjSk8uEvuND4s_bwWuntkS5f3ya1Bc0r_gPweVj90QacabxXniymtMpqX6J5iYoIqPcfT6oK2VbBUoZM6z80VC6CkUq2Wmk4gRJ6Pi1rpaS6pLFPaJoppgy5EJWjNuqgLqmoFYYCmwd-fv8amkzZ40uZtrgxVhfX9FJhYzSbVYjaB8Yfk9Fo494hsl1WpnxAaCM8Rwk9gWofBL06k8LOQJT7njmZhYJG9lkWxapqlI2ZHEXdBU5rHhpsWed2RztYdQi4i-oJ87giwqbd5Uc3HcaMj4lREkRaZ5wutII4UiVIRrplJrbzUcS2y20pJ3GiaRWxcWh_l7ZLhdttY5FU3DCoEz4VkqasV0KAPGSImpkUer2Wu-1AzFArfImJDGjdWsjlS5hPTplz4ImQ455tObq_6QXtGoi-niA_3--bh6dXrfEl2eieD4_i4Pzx6Rm57mB8x5dW7ZHs5X-nn4EQukxdm51Jydt2q4h-oDofM |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwELZKkQoXxD-BAuZP6iU0iRM7OSAELKtuS1ccqLS31HGc3UjZZNkfqtx4BJ6Ch-BxeBJmvEmkFW1vvUXxyIoz429-PJ4h5LUAIYm4BPTzU2b7oONsmfLAzqQbZr4vQ9d0iTge8oMT_3AUjLbIn_YuDKZVtphogDqtFMbI90ENhVg83Iv2syYt4muv_3723cYOUnjS2rbTWIvIka7PwH1bvBv0gNdvPK__-dunA7vpMGArHgTcVpHDdJRlCpSU1kpwUH-BjBLFPezE7CrXkQDYjpcGWiaZLyOZyCANwKfUWaQyBvNeI9cF8xmmk4mR6OI7WGWFmwa2HibtAaTwprCRSSRK87cubCe-oQ5N14DzTN3_MzZvrMqZrM9kUWxa1UYt9m-TW409Sz-sBfAO2dLlXbJz3JzY3yO_h9UPXdCpxhvG-WJKq4zmJZqqGKSgSs_x5LqgbUYsVWiwznNz3QIoqVSrpaYTcJfn46JWeppLKsuUtkFj2nQaohIQtC7qgqpagUugafD356-xqaoNVrV5mytDVWGuPwUmVrNJtZhNYPw-ObkSzj0g22VV6keEBsJzhGAJTOv48IsTKVgW-gnj3NF-GFhkr2VRrJrC6di_o4g7ByrNY8NNi7zsSGfraiHnEX1EPncEWODbvKjm47jBizgVUaRF5jGhFfiUIlEqwjX7UisvdVyL7LZSEjeos4iNectQ3i4YbreQRV50wwAneEYkS12tgAbtyRD7Y1rk4Vrmug81Q6FgFhEb0rixks2RMp-YkuWCidDHOV91cnvZD9ozEn0xRXzYG5iHx5ev8znZAZCIvwyGR0_ITQ9DJSbTepdsL-cr_RTsyWXyzGxcSk6vGin-AejojAc |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LbtQwFLVgKkE3vKGBgsxj0U2GPOw4WZZHVSp1xIKRyio4jj0TkUlG8wANKz6Br-DD-BLudTJBgRYhsYviGytOjq-P7etzCXkmACRJJMH7sTx0GYxxrswj7hrpx4YxGfs2S8TpKDoes5MzftbmOcWzMI0-RLfghj3D-mvs4PPcNH7-eRePkxdDH1AZXSY7Ee4wDcjOePT28D2mlMNYOTCKfl0HrNUW6j3bG5GscP95bPPPoMmr62ouN59lWfaJrR2Zjq6TD9s2NQEpH4frVTZUX36Te_yPRt8g11rWSg8bmN0kl3R1i1w5bfflb5Pvo_qTLulM4zniYjmjtaFFhYQUlyKo0gvcny7pNu6VKqSli8IeqgBLKtV6pekUJsWLSblRelZIKqucbpeGaZtPiErwk5tyU1K1UUD8NeU_vn6bWO1s4M72bqGsVY0R_RR6WT2f1sv5FMrvkPHR63cvj902A4SrIs4jVyVeqBNjFJAIrZWIgJ5wmWQqCjBTtq98T8KA6gU51zIzTCYykzznMOfXJlEmvEsGVV3pPUK5CDwhwgyq9Rj8xUyK0MQsCwE3msXcIQdbFKSqlUfHLB1l2k2T8iK1390hTzrTeaMJcp7RC4RSZ4Ay3vZGvZikrVdIc5EkWpggFFrBzFFkSiXYZia1CnLPd8j-Fohp61uWqSWxIUL6gmIWo8p-kDjkcVcMTgN3gmSl6zXYIGuMMQumQ-41sO5e1BbFInSI6AG-15J-SVVMrTC5CEXMsM6nXdf42wc6sEi_2CI9efXGXtz_pwofkN0AF0NsLPU-GawWa_0QGOMqe9R6hZ_mnG41 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+mechanism+of+increasing+cerebral+vascular+constriction+in+acute+hyperglycemia+and+diabetes+through+adenylyl+cyclase+5%E2%80%90generated+cyclic+adenosine+monophosphate&rft.jtitle=Journal+of+diabetes+investigation&rft.au=Sakamoto%2C+Kenichi&rft.au=Yokote%2C+Koutaro&rft.date=2020-07-01&rft.pub=John+Wiley+and+Sons+Inc&rft.issn=2040-1116&rft.eissn=2040-1124&rft.volume=11&rft.issue=4&rft.spage=783&rft.epage=785&rft_id=info:doi/10.1111%2Fjdi.13186&rft_id=info%3Apmid%2F31758873&rft.externalDocID=PMC7378430 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2040-1116&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2040-1116&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2040-1116&client=summon |