Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5‐generated cyclic adenosine monophosphate

• Published in: Journal of diabetes investigation Vol. 11; no. 4; pp. 783 - 785
• Main Authors: Sakamoto, Kenichi, Yokote, Koutaro
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.07.2020; John Wiley and Sons Inc; Wiley
• Subjects: Acute Disease; Adenosine triphosphate; Adenylate cyclase; Adenylyl Cyclases - metabolism; Animal models; Calcium channels; Calcium channels (voltage-gated); Cerebrovascular Circulation - physiology; Commentaries; Constriction; Contractility; Cyclic AMP; Cyclic AMP - metabolism; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Epidemiology; Glucose; Humans; Hyperglycemia; Hyperglycemia - etiology; Hyperglycemia - physiopathology; Hypertension; Kinases; Myocytes; Pathophysiology; Protein kinase A; Proteins; Veins & arteries
• ISSN: 2040-1116; 2040-1124; 2040-1124
• DOI: 10.1111/jdi.13186

Epidemiological and functional studies show that impaired arterial myocyte contractility contributes to vascular complications in diabetes patients and animal models of diabetes . [...]to clarify the mechanism of how hyperglycemia increases vascular tone is an important subject of diabetes research. Because AC6 is not close to the CaV1.2 in the previous report, this intimate spatial organization might be an important role for local PKA‐dependent regulation of L‐type Ca2+ channels in arterial myocytes. [...]the authors analyzed the function of AC5 in diabetes model mice. [...]the discrepancy of canonical function of PKA is still unknown.