Sonodynamic therapy on chemically induced mammary tumor : Pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of porfimer sodium

• Published in: Cancer science Vol. 95; no. 9; pp. 765 - 769
• Main Authors: Yumita, Nagahiko, Okuyama, Nobuo, Sasaki, Kazuaki, Umemura, Shin‐ichiro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2004; Blackwell; John Wiley & Sons, Inc
• Subjects: 9,10-Dimethyl-1,2-benzanthracene - toxicity; Animals; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - therapeutic use; Antitumor activity; Biological and medical sciences; Carcinogens - toxicity; Cavitation; Combined Modality Therapy; Dihematoporphyrin Ether - pharmacokinetics; Dihematoporphyrin Ether - therapeutic use; Female; Growth inhibition; Mammary gland; Mammary Neoplasms, Animal - chemically induced; Mammary Neoplasms, Animal - therapy; Medical sciences; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tumors; Ultrasonic Therapy; Antineoplastic agent; Porfimer sodium; Cancerology; Treatment; Tumoral tissue; Distribution; Mammary gland; Pharmacokinetics
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/j.1349-7006.2004.tb03259.x

The sonodynamically induced antitumor effect of porfimer sodium (PF) was evaluated on a chemically induced mammary tumor in Sprague‐Dawley rats. The timing of 24 h after the administration of PF was chosen for the ultrasonic exposure, based on pharmacokinetic analysis of the PF concentrations in the tumor, plasma, skin and muscle. At a PF dose not less than 2.5 mg/kg and at a free‐field ultrasonic intensity not less than 3 W/cm2, the synergistic effect between PF administration and ultrasonic exposure on the tumor growth inhibition was significant. The ultrasonic intensity showed a relatively sharp threshold for the synergistic antitumor effect, which is typical of an ultrasonic effect mediated by acoustic cavitation. These results suggest that PF is a potentially useful as a sonosensitizer for sonodynamic treatment of chemically induced tumors.