Genomewide Association Analysis of Coronary Artery Disease

• Published in: The New England journal of medicine Vol. 357; no. 5; pp. 443 - 453
• Main Authors: Samani, Nilesh J, Erdmann, Jeanette, Hall, Alistair S, Hengstenberg, Christian, Mangino, Massimo, Mayer, Bjoern, Dixon, Richard J, Meitinger, Thomas, Braund, Peter, Wichmann, H.-Erich, Barrett, Jennifer H, König, Inke R, Stevens, Suzanne E, Szymczak, Silke, Tregouet, David-Alexandre, Iles, Mark M, Pahlke, Friedrich, Pollard, Helen, Lieb, Wolfgang, Cambien, Francois, Fischer, Marcus, Ouwehand, Willem, Blankenberg, Stefan, Balmforth, Anthony J, Baessler, Andrea, Ball, Stephen G, Strom, Tim M, Brænne, Ingrid, Gieger, Christian, Deloukas, Panos, Tobin, Martin D, Ziegler, Andreas, Thompson, John R, Schunkert, Heribert
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 02.08.2007
• Subjects: Biological and medical sciences; Cardiology. Vascular system; Cardiovascular disease; Chromosomes, Human, Pair 2 - genetics; Chromosomes, Human, Pair 6 - genetics; Chromosomes, Human, Pair 9 - genetics; Coronary Artery Disease - genetics; Coronary heart disease; Coronary vessels; Female; Gene loci; General aspects; Genetic Markers; Genetic Predisposition to Disease; Genome, Human; Genotype; Heart; Heart attacks; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - genetics; Polymorphism, Single Nucleotide; Risk; Medicine; Cardiovascular disease; Association; Coronary heart disease
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa072366

Using the technique of genomewide association analysis, the authors found a locus on chromosome 9 (9p21.3) that is strongly associated with familial coronary artery disease. The precise gene that may be involved is not known and will require further study, but this type of genomic analysis is likely to lead to a deeper understanding of the pathogenesis of coronary artery disease and other chronic diseases. Using the technique of genomewide association analysis, the authors found a locus on chromosome 9 that is strongly associated with familial coronary artery disease. Coronary artery disease and its main complication, myocardial infarction, are leading causes of death and disability worldwide. 1 Lifestyle and environmental factors play an important role in their development. 2 In addition, these complex diseases cluster in families, suggesting a substantial genetic cause. 3 Despite extensive exploration of many genes, strong evidence of a molecular genetic association with coronary artery disease or myocardial infarction remains to be obtained. The recent development of high-density genotyping arrays provides unprecedented resolution for whole-genome assessment of variants associated with common diseases. 4 Using the GeneChip Human Mapping 500K Array Set (Affymetrix), which simultaneously types approximately 500,000 genetic variants, . . .