丝裂原活化蛋白激酶磷酸酶-1在妇产科相关疾病中的研究进展

丝裂原活化蛋白激酶磷酸酶（mitogen-activated kinase phosphatase,MKPs）是一类在细胞内水解丝裂原活化蛋白激酶（mitogen-activated protein kinases,MAPKs）的家族,通过负向调控MAPKs参与细胞的应激、分化、增殖、凋亡等细胞过程,其异常表达与肿瘤的发生、发展密切相关。MKP-1是MKPs家族中被报道最多的成员,具有最强的去磷酸化能力。综述MKP-1在妇产科相关疾病,包括生殖器肿瘤、子宫内膜异位症以及子痫前期的研究进展,阐述MKP-1在疾病中的表达特征、病理作用及其机制;重点讨论了MKP-1在子宫内膜异位症发生发展中的作用,...

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Published in国际生殖健康/计划生育杂志 Vol. 35; no. 2; pp. 155 - 159
Main Author 苏琳 陈琼华
Format Journal Article
LanguageChinese
Published 厦门大学附属第一医院妇产科, 福建省厦门市,361004 2016
Subjects
丝裂原激活蛋白激酶类
先兆子痫
双特异性磷酸酶1
子宫内膜异位症
生殖器肿瘤,女（雌）性
子宫内膜异位症
生殖器肿瘤,女(雌)性
丝裂原激活蛋白激酶类
先兆子痫
Genital neoplasms,female
Endometriosis
双特异性磷酸酶1
Dual specificity phosphatase 1
Pre-eclampsia
Mitogen-activated protein kinases
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ISSN1674-1889

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Summary:丝裂原活化蛋白激酶磷酸酶（mitogen-activated kinase phosphatase,MKPs）是一类在细胞内水解丝裂原活化蛋白激酶（mitogen-activated protein kinases,MAPKs）的家族,通过负向调控MAPKs参与细胞的应激、分化、增殖、凋亡等细胞过程,其异常表达与肿瘤的发生、发展密切相关。MKP-1是MKPs家族中被报道最多的成员,具有最强的去磷酸化能力。综述MKP-1在妇产科相关疾病,包括生殖器肿瘤、子宫内膜异位症以及子痫前期的研究进展,阐述MKP-1在疾病中的表达特征、病理作用及其机制;重点讨论了MKP-1在子宫内膜异位症发生发展中的作用,阐述了MKP-1与MAPKs的相互作用对子宫内膜异位症发生、发展过程的影响,为今后的研究方向提供参考。
Bibliography:Mitogen-activated protein kinases; Dual specificity phosphatase 1; Genital neoplasms; female; Endometriosis; Pre-eclampsia
The mitogen-activated kinase phosphatase（MKPs）,a intracellular phosphatase family that could hydrolyze the mitogen-activated protein kinases（MAPKs） in cells,participate in the regulation of cell stress,differentiation,proliferation and apoptosis by the negative feedback regulation of MAPKs. The abnormal expression of MKP-1 was associated with the cancer occurrence and development. MKP-1 shows the strongest ability of dephosphorylation,which has been well studied as a member of the MKPs family. In this review,we summarized the effects of MKP-1 in the diseases associated with obstetrics and gynecology,including genital neoplasms,endometriosis and preeclampsia. The expression pattern,pathological function and molecular mechanism of MKP-1 in obstetrical and gynecological diseases were elucidated. After that,we focused on the pathophysiological effect of MKP-1 in endometriosis. The interaction
ISSN:1674-1889