长效GnRHa在子宫内膜异位症合并不孕中的应用进展
子宫内膜异位症(EMs)是一种常见妇科疾病,生育期妇女EMs发病率约10%~15%,高达50%的EMs患者伴有不孕。促性腺激素释放激素激动剂(GnRHa)是治疗EMs的常用药,可通过不同作用机制作用于下丘脑-垂体系统和子宫内膜。多数报道肯定了保守性手术术后GnRHa治疗在提高EMs合并不孕患者的妊娠率以及降低复发率上的疗效。在预防卵巢子宫内膜异位囊肿术后复发、缓解深部浸润型EMs疼痛方面,GnRHa也有一定的疗效。在治疗青春期EMs方面,多应用GnRHa联合激素反加疗法,以提高患者生活质量。GnRHa超长方案并不影响鲜胚移植的获卵数,冻胚移植前GnRHa预处理也可提高体外受精(IVF)成功率。...
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Published in | 国际生殖健康/计划生育杂志 Vol. 36; no. 4; pp. 335 - 339 |
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Main Author | |
Format | Journal Article |
Language | Chinese |
Published |
山东大学, 济南,250012
2017
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Subjects | |
Online Access | Get full text |
ISSN | 1674-1889 |
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Summary: | 子宫内膜异位症(EMs)是一种常见妇科疾病,生育期妇女EMs发病率约10%~15%,高达50%的EMs患者伴有不孕。促性腺激素释放激素激动剂(GnRHa)是治疗EMs的常用药,可通过不同作用机制作用于下丘脑-垂体系统和子宫内膜。多数报道肯定了保守性手术术后GnRHa治疗在提高EMs合并不孕患者的妊娠率以及降低复发率上的疗效。在预防卵巢子宫内膜异位囊肿术后复发、缓解深部浸润型EMs疼痛方面,GnRHa也有一定的疗效。在治疗青春期EMs方面,多应用GnRHa联合激素反加疗法,以提高患者生活质量。GnRHa超长方案并不影响鲜胚移植的获卵数,冻胚移植前GnRHa预处理也可提高体外受精(IVF)成功率。 |
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Bibliography: | ZHAO Ying,YAN Lei (Shandong University,Jinan 250012,China;Reproduction Hospital Affiliated to Shandong University,Jinan 250012,China) Endometriosis ; Gonadotropin-releasing hormone ; Infertility ; female; Reproductive techniques ; assisted ; Pregnancy rate Endometriosis (EMs) is a common gynecological disease. The incidence of EMs in reproductive women is about 10% to 15%, and up to 50% of EMs patients are infertile. Gonadotropin releasing hormone agonists (GnRHa), commonly used in the treatment of EMs, act on the hypothalamus pituitary system and endometrium through different mechanisms. Most reports confirmed the efficacy of GnRHa treatment after conservative surgery in increasing the pregnancy rate and decreasing relapse rate in EMs patients with infertility. GnRHa can also play a certain role in preventing the recurrence of ovarian endometriosis and alleviating the pain of deep invasive endometriosis. GnRHa and hormonal reverse therapy are often applied to improve the life quality of patients with adolescen |
ISSN: | 1674-1889 |