Automated VMAT planning for short-course radiotherapy in locally advanced rectal cancer

• Published in: PloS one Vol. 20; no. 6; p. e0325567
• Main Authors: Zhou, Qiong, Qian, Liwen, Shen, Chong, Bei, Xinyan, Liu, Gaojie, Sun, Xiaonan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.06.2025; Public Library of Science (PLoS)
• Subjects: Aged; Automation; Biology and Life Sciences; Bladder; Cancer; Cancer therapies; Care and treatment; Colorectal cancer; Drug dosages; Efficiency; Feasibility; Feedback; Female; Humans; Male; Medical laboratories; Medicine and Health Sciences; Methods; Middle Aged; Objectives; Optimization algorithms; Organs at Risk - radiation effects; Parameters; Patients; Physical Sciences; Planning; Quality assurance; Radiation dosimetry; Radiation therapy; Radiotherapy; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted - methods; Radiotherapy, Intensity-Modulated - methods; Rectal Neoplasms - pathology; Rectal Neoplasms - radiotherapy; Rectum; Research and Analysis Methods; Retrospective Studies; Small intestine; Technology application; China; Monaco; Sweden
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0325567

This study aims to develop a fully automated VMAT planning program for short-course radiotherapy (SCRT) in Locally Advanced Rectal Cancer (LARC) and assess its plan quality, feasibility, and efficiency. Thirty LARC patients who underwent short-course VMAT treatment were retrospectively selected from our institution for this study. An auto-planning program for neoadjuvant short-course radiotherapy (SCRT) in LARC was developed using the RayStation scripting platform integrated with the Python environment. The patients were re-planned using this auto-planning program. Subsequently, the differences between the automatic plans (APs) and existing manual plans (MPs) were compared in terms of plan quality, monitor units (MU), plan complexity, and other dosimetric parameters. Plan quality assurance (QA) was performed using the ArcCHECK dosimetric verification system. Compared to MPs, the APs achieved similar target coverage and conformity, while providing more rapid dose fall-off. Except for the V5Gy dose level, other dosimetric metrics (V25 Gy, V23 Gy, V15 Gy, Dmean, etc.) for the small bowel were significantly lower in the AP compared to the MP (p < 0.001). Additionally, the dosimetric parameters for the bladder, pelvic marrow, and femoral head were also lower in the AP, except for the V25Gy for the bladder. The MUs of the AP were approximately 4% lower than those of the MP. The AP showed high consistency in dosimetric parameters across five organs at risk (OARs). We developed a fully automated, feasible SCRT VMAT planning program for LARC. This program significantly enhanced plan quality and efficiency while substantially reducing the dose to OARs.