阿莫西林/克拉维酸钾联合常规抗结核药治疗耐多药肺结核的疗效观察

目的：探讨阿莫西林/克拉维酸钾联合常规抗结核药治疗耐多药肺结核（multidrug resistance tuberculosis,MDR-TB）的临床疗效和不良反应。方法：将205例MDR-TB患者按随机数字表法分为观察组103例和对照组102例。对照组患者给予吡嗪酰胺、乙胺丁醇、对氨基水杨酸异烟肼、利福喷丁和左氧氟沙星,观察组患者在对照组治疗的基础上加用阿莫西林/克拉维酸钾,2组疗程均为12个月。观察患者的痰菌阴转、病灶吸收、空洞闭合和不良反应发生情况。结果：治疗3个月后,2组患者痰菌阴转率的差异无统计学意义（P〉0.05）;治疗6、9、12个月后,观察组患者痰菌阴转率分别为68.93%（...

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Bibliographic Details
Published in中国医院用药评价与分析 no. 9; pp. 1142 - 1144
Main Author 郭蕊 焦雪峰 陈爽 罗琳
Format Journal Article
LanguageChinese
Published 河南省胸科医院药剂科,河南郑州,450000 2015
Subjects
病灶吸收
痰菌阴转率
空洞闭合
耐多药肺结核
阿莫西林/克拉维酸钾
痰菌阴转率
Amoxycillin/clavulanate potassium
耐多药肺结核
Sputum negative conversion
病灶吸收
阿莫西林/克拉维酸钾
空洞闭合
Focal absorption
Multidrug resistance tuberculosis
Cavity closure
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ISSN1672-2124
DOI10.14009/j.issn.1672-2124.2015.09.003

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Summary:目的：探讨阿莫西林/克拉维酸钾联合常规抗结核药治疗耐多药肺结核（multidrug resistance tuberculosis,MDR-TB）的临床疗效和不良反应。方法：将205例MDR-TB患者按随机数字表法分为观察组103例和对照组102例。对照组患者给予吡嗪酰胺、乙胺丁醇、对氨基水杨酸异烟肼、利福喷丁和左氧氟沙星,观察组患者在对照组治疗的基础上加用阿莫西林/克拉维酸钾,2组疗程均为12个月。观察患者的痰菌阴转、病灶吸收、空洞闭合和不良反应发生情况。结果：治疗3个月后,2组患者痰菌阴转率的差异无统计学意义（P〉0.05）;治疗6、9、12个月后,观察组患者痰菌阴转率分别为68.93%（71/103）、74.76%（77/103）和81.55%（84/103）,均明显高于对照组的50.98%（52/102）、55.88%（57/102）和60.78%（62/102）,差异有统计学意义（P〈0.05）;疗程结束时观察组与对照组患者的病灶吸收总有效率分别为88.35%（91/103）和66.67%（68/102）,空洞闭合总有效率分别为84.47%（87/103）和64.71%（66/102）,观察组均明显优于对照组,差异均有统计学意义（P〈0.05）。结论：阿莫西林/克拉维酸钾联合常规抗结核药治疗MDRTB安全、有效,但短期疗效优势不明显。
Bibliography:OBJECTIVE： To probe into the clinical efficacy and adverse drug reaction of amoxycillin / clavulanate potassium combined with conventional anti- TB drugs in treatment of multidrug resistance tuberculosis（ MDR-TB）.METHODS： 205 MDR-TB patients were divided into treatment group（ 103 patients） and control group（ 102 patients）by random number table. The control group was given amoxycillin,ethambutol,isoniazid aminosalicylate,rifapentine and levofloxacin,the observation group received amoxycillin / clavulanate potassiumthe based on the same treatment regimen of the control group. The treatment course of 2 groups was 12 months. The changes of sputum negative conversion,focal absorption,cavity,the improved clinical symptoms and negative ADR consequences were closely observed in two groups. RESULTS： After the treatment of 3 months,there was no statistically significant difference of the sputum negative conversion rate in 2 groups（ P 0. 05）. In the treatment group,the sputum negative rate at the sixth,ninth and twelfth
ISSN:1672-2124
DOI:10.14009/j.issn.1672-2124.2015.09.003