Association of periostin expression with eosinophilic inflammation in nasal polyps

• Published in: Journal of allergy and clinical immunology Vol. 136; no. 6; pp. 1700 - 1703.e9
• Main Authors: Wang, Min, Wang, Xiangdong, Zhang, Nan, Wang, Hong, Li, Ying, Fan, Erzhong, Zhang, Liang, Zhang, Luo, Bachert, Claus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Allergy and Immunology; Asthma; Cell Adhesion Molecules - blood; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - immunology; Chemokine CCL11 - immunology; Cytokines; Cytokines - immunology; Eosinophil Cationic Protein - immunology; Eosinophilia - immunology; Female; Fibronectins - immunology; Humans; Inflammation - immunology; Male; Middle Aged; Nasal Polyps - blood; Nasal Polyps - immunology; Proteins; Rhinitis - blood; Rhinitis - immunology; Sinusitis - blood; Sinusitis - immunology; Studies; Tenascin - genetics; Tenascin - immunology; Young Adult
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2015.09.005

Periostin expression has been shown to be regulated by several mediators, including TGF-β1, TGF-β2, and TGF-β4; bone morphogenic proteins 2 and 4; vascular endothelial growth factor; and IL-3, IL-4, IL-6, and IL-13.5 Our study showed that concomitant with the significantly increased periostin expression in nasal tissue of IL-5high patients with CRSwNP, expression of IL-4 and IL-13, but not IFN-γ, IL-17, and TGF-β1 (Fig 1, E), was also significantly increased in IL-5high patients with CRSwNP compared with that seen in IL-5low patients with CRSwNP and control subjects, with a significant correlation between periostin and IL-4 expression (r = 0.342, P = .038). Periostin has been reported to interact with extracellular matrix (ECM) proteins, such as type 1 collagen, fibronectin, tenascin C, and heparin.10 Accordingly, our results showed that the expression patterns of fibronectin and tenascin C were similar to that of periostin (Fig 1, F), with tenascin C expression correlated with periostin expression (r = 0.397, P = .015) in patients with CRSwNP and fibronectin and tenascin C expression colocalized with eosinophil counts and periostin expression in the subepithelial region of NP tissue (Fig 2, A). [...]eosinophils adhered to fibronectin and tenascin C (Fig 2, D).