不明原因胚胎停育绒毛和蜕膜组织芳香烃受体和细胞色素P4501A1蛋白的表达及意义

目的：探讨芳香烃受体（aryl hydrocarbon receptor,AhR）和细胞色素P4501A1（cytochrome P4501A1,CYP1A1）蛋白在胚胎停育患者绒毛及蜕膜中的表达。方法：分别选取30例不明原因胚胎停育患者作为病例组和30例正常早期妊娠人工流产妇女作为对照组,采用免疫组织化学方法检测2组患者绒毛和蜕膜组织中AhR和CYP1A1蛋白表达水平。结果：绒毛组织中,病例组AhR蛋白表达水平（0.58±0.03）高于对照组（0.25±0.04）,病例组CYP1A1蛋白表达水平（0.60±0.01）高于对照组（0.22±0.03）,差异均有统计学意义（P〈0.05）。蜕膜组...

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Published in国际生殖健康/计划生育杂志 Vol. 36; no. 6; pp. 451 - 453
Main Author 王云凤 连立芬 侯海燕 梁婧 陈俊 陈亚琼 董渠龙
Format Journal Article
LanguageChinese
Published 中国人民武装警察部队后勤学院附属医院妇产科%秦皇岛市妇幼保健院%中国人民武装警察部队后勤学院附属医院妇产科%中国中医科学院广安门医院南区 2017
300193 天津中医药大学
Subjects
CYP1A1
烃类,芳香
细胞色素P450
绒毛
胚胎丢失
胚胎停育
蜕膜
烃类,芳香
细胞色素P450CYP1A1
绒毛
Embryo loss
Hydrocarbons,aromatic
蜕膜
胚胎停育
Chorion
Cytochrome P-450 CYP1A1
胚胎丢失
Decidua
Embryonic diapauses
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ISSN1674-1889
DOI10.3969/j.issn.1674-1889.2017.06.002

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Summary:目的：探讨芳香烃受体（aryl hydrocarbon receptor,AhR）和细胞色素P4501A1（cytochrome P4501A1,CYP1A1）蛋白在胚胎停育患者绒毛及蜕膜中的表达。方法：分别选取30例不明原因胚胎停育患者作为病例组和30例正常早期妊娠人工流产妇女作为对照组,采用免疫组织化学方法检测2组患者绒毛和蜕膜组织中AhR和CYP1A1蛋白表达水平。结果：绒毛组织中,病例组AhR蛋白表达水平（0.58±0.03）高于对照组（0.25±0.04）,病例组CYP1A1蛋白表达水平（0.60±0.01）高于对照组（0.22±0.03）,差异均有统计学意义（P〈0.05）。蜕膜组织中,病例组AhR蛋白表达水平（0.56±0.03）高于对照组（0.26±0.04）,病例组CYP1A1蛋白表达水平（0.57±0.01）高于对照组（0.24±0.03）,差异均有统计学意义（P〈0.05）。结论：胚胎停育患者绒毛和蜕膜组织中AhR和CYP1A1蛋白表达明显增高,可能与不明原因胚胎停育的发生有关。
Bibliography:Objective：To test the expressions of aryl hydrocarbon receptor（AhR） and cytochrome P4501A1（CYP1A1） protein in the chorionic and decidual tissues of embryonic diapause. Methods：30 cases of early unexplained embryonic diapauses（the study group） and 30 cases of induced abortion in normal early pregnancy（the control group） were selected. The expression levels of AhR and CYP1A1 in the chorionic tissues and decidual tissues were detected by immunohistochemical method. Results：The study group had significantly high expression of AhR protein in the chorionic tissues（0.58±0.03, P〈0.01） and the decidual tissues（0.56±0.03,P〈0.01） when compared with the control group（0.25 ±0.04, 0.26 ±0.04）. Meanwhile, the study group had significantly high expression of CYP1A1 protein in the chorionic tissues（0.60 ±0.01, P〈0.01） and the decidual tissues（0.57±0.01, P〈0.01） when compared with the control group（0.22 ±0.03, 0.24 ±0.03）. Conclusions：The increased expressions of AhR and CYP1A1 protein in the chorionic and decidual tissues may
ISSN:1674-1889
DOI:10.3969/j.issn.1674-1889.2017.06.002