Deep phenotyping of dementia in a multi-ethnic cardiovascular cohort: The Multi-Ethnic Study of Atherosclerosis (MESA)

• Published in: PloS one Vol. 19; no. 4; p. e0298952
• Main Authors: Ostovaneh, Mohammad R., Hughes, Timothy M., Wu, Colin O., McClelland, Robyn L., Casanova, Ramon, Bluemke, David A., Tracy, Russell P., Shea, Steven, Heckbert, Susan R., Lima, João A. C., Ambale-Venkatesh, Bharath
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.04.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Atherosclerosis; Biology and Life Sciences; Cardiovascular Diseases; Care and treatment; Carotid Intima-Media Thickness; Computer and Information Sciences; Coronary Artery Disease; Dementia; Dementia - diagnosis; Diagnosis; Electrocardiogram; Electrocardiography; Exercise; Health aspects; Humans; Incidence; Inflammation; Life expectancy; Liver; Medicine and Health Sciences; Neoplasms; Phenotype; Risk Factors; United States
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0298952

Our understanding of the specific aspects of vascular contributions to dementia remains unclear. We aim to identify the correlates of incident dementia in a multi-ethnic cardiovascular cohort. A total of 6806 participants with follow-up data for incident dementia were included. Probable dementia diagnoses were identified using hospitalization discharge diagnoses according to the International Classification of Diseases Codes (ICD). We used Random Forest analyses to identify the correlates of incident dementia and cognitive function from among 198 variables collected at the baseline MESA exam entailing demographic risk factors, medical history, anthropometry, lab biomarkers, electrocardiograms, cardiovascular magnetic resonance imaging, carotid ultrasonography, coronary artery calcium and liver fat content. Death and stroke were considered competing events. Over 14 years of follow-up, 326 dementia events were identified. Beyond age, the top correlates of dementia included coronary artery calcification, high sensitivity troponin, common carotid artery intima to media thickness, NT-proBNP, physical activity, pulse pressure, tumor necrosis factor-α, history of cancer, and liver to spleen attenuation ratio from computed tomography. Correlates of cognitive function included income and physical activity, body size, serum glucose, glomerular filtration rate, measures of carotid artery stiffness, alcohol use, and inflammation indexed as IL-2 and TNF soluble receptors and plasmin-antiplasmin complex. In a deeply phenotyped cardiovascular cohort we identified the key correlates of dementia beyond age as subclinical atherosclerosis and myocyte damage, vascular function, inflammation, physical activity, hepatic steatosis, and history of cancer.