Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial

• Published in: BMC gastroenterology Vol. 19; no. 1; pp. 133 - 6
• Main Authors: Saadati, Saeede, Sadeghi, Amir, Mansour, Asieh, Yari, Zahra, Poustchi, Hossein, Hedayati, Mehdi, Hatami, Behzad, Hekmatdoost, Azita
• Format: Journal Article
• Language: English
• Published: London BioMed Central 25.07.2019; BioMed Central Ltd; BMC
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Care and treatment; Curcumin; Curcumin - administration & dosage; Dietary supplements; Fatty liver; Female; Gastroenterology; Health aspects; Hepatology; Humans; Inflammation; Inflammation - drug therapy; Inflammation - pathology; Internal Medicine; Liver - drug effects; Liver - pathology; Liver Function Tests - methods; Male; Medicine; Medicine & Public Health; Middle Aged; NAFLD; NASH; NF-kappa B - analysis; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - pathology; Non-alcoholic Fatty Liver Disease - psychology; Non-alcoholic Fatty Liver Disease - therapy; Nutrition and metabolism; Research Article; Risk Reduction Behavior; Testing; Treatment Outcome; Tumor Necrosis Factor-alpha - analysis; Turmeric; Iran; NAFLD; Curcumin; Inflammation; Fatty liver; NASH
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-019-1055-4

Background The aim of the present study was to evaluate the effects of curcumin supplementation on inflammatory indices, and hepatic features in patients with non-alcoholic fatty liver disease (NAFLD). Methods Fifty patients with NAFLD were randomized to receive lifestyle modification advice plus either 1500 mg curcumin or the same amount of placebo for 12 weeks. Results Curcumin supplementation was associated with significant decrease in hepatic fibrosis ( p  < 0.001), and nuclear factor-kappa B activity ( p  < 0.05) as compared with the baseline. Hepatic steatosis and serum level of liver enzymes, and tumor necrosis-α (TNF-α) significantly reduced in both groups ( p  < 0.05). None of the changes were significantly different between two groups. Conclusion Our results indicated that curcumin supplementation plus lifestyle modification is not superior to lifestyle modification alone in amelioration of inflammation. Trial registration IRCT20100524004010N24 , this trial was retrospectively registered on May 14, 2018.