精神分裂症患者急性期药物治疗前后的脑灰质变化
探讨短期药物治疗对精神分裂症急性期患者大脑结构（尤其是灰质）的影响。方法·共27例未服药的早期精神分裂症患者（病程不超过5年）和21名健康志愿者入组，其中27例患者接受抗精神病药物治疗8周，分别于基线及8周后（21例精神分裂症患者及21例健康志愿者）进行3T磁共振扫描。使用基于体素的形态学分析（VBM）方法分析大脑灰质体积及其变化。结果·与健康对照组比较，精神分裂症患者的左侧小脑后叶、左侧颞中回及双侧海马旁回的灰质容积减少（P=0.000，体素>50)。8周后随访，健康对照组的灰质体积无变化。经抗精神病药物治疗8周后，精神分裂症患者较多脑区的灰质容积缩小，主要包括双侧颞上回、颞中...
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| Published in | 上海交通大学学报（医学版） Vol. 37; no. 2; pp. 203 - 206 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海交通大学 医学院附属精神卫生中心精神病性障碍科,上海,200030%中国科学院 神经科学研究所,上海,200031
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-8115 |
| DOI | 10.3969/j.issn.1674-8115.2017.02.014 |
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| Summary: | 探讨短期药物治疗对精神分裂症急性期患者大脑结构（尤其是灰质）的影响。方法·共27例未服药的早期精神分裂症患者（病程不超过5年）和21名健康志愿者入组，其中27例患者接受抗精神病药物治疗8周，分别于基线及8周后（21例精神分裂症患者及21例健康志愿者）进行3T磁共振扫描。使用基于体素的形态学分析（VBM）方法分析大脑灰质体积及其变化。结果·与健康对照组比较，精神分裂症患者的左侧小脑后叶、左侧颞中回及双侧海马旁回的灰质容积减少（P=0.000，体素>50)。8周后随访，健康对照组的灰质体积无变化。经抗精神病药物治疗8周后，精神分裂症患者较多脑区的灰质容积缩小，主要包括双侧颞上回、颞中回、颞下回，双侧额上回、额中回、额下回，双侧海马旁回及扣带回，右侧缘上回，右侧小脑后叶，右侧舌状回(P=0.000，体素>50)。结论·抗精神病药物短期治疗（8周）对急性期精神分裂症患者的大脑灰质可能产生不利影响，引起灰质体积的缩小。 |
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| Bibliography: | 31-2045/R schizophrenia; grey matter; voxel-based morphometry; antipsychotics; magnetic resonance imaging To observe the changes of cerebral gray matter pre- and post-treatment with short term drugs in patients with schizophrenia.Methods · T1-weighted brain MRIs were obtained on a 3T scanner in 21 controls and 27 subjects with schizophrenia who were not given antipsychotic medication. The controls and 21 schizophrenia patients received the second scan after 8 weeks of antipsychotic treatment. Voxel-based morphometry (VBM) were used to investigate the differences in gray matter (GM), mainly about the regional GM volumes. Results · GM volumes were significantly smaller in the patient group than those of healthy controls in left cerebellum posterior lobe , left and right parahippocampalgyrus, left middle temporalgyrus(P=0.000, voxels>50). GM volumes extensively decreased after 8 weeks of antipsychotic-treatment compared with pre-treatment in the superior,middle, and inferior temporal gyri, superior,middle and i |
| ISSN: | 1674-8115 |
| DOI: | 10.3969/j.issn.1674-8115.2017.02.014 |