Quercetin with the potential effect on allergic diseases

• Published in: Allergy, asthma, and clinical immunology Vol. 16; no. 1; pp. 36 - 11
• Main Authors: Jafarinia, Morteza, Sadat Hosseini, Mahnaz, kasiri, Neda, Fazel, Niloofar, Fathi, Farshid, Ganjalikhani Hakemi, Mazdak, Eskandari, Nahid
• Format: Journal Article
• Language: English
• Published: London BioMed Central 14.05.2020; BioMed Central Ltd; BMC
• Subjects: Airway management; Allergies; Allergology; Allergy; Asthma; Atopic dermatitis; B cells; Bioflavonoids; Cytokines; Eczema; Flavones; Flavonoids; Gene expression; Genotype & phenotype; Histamine; Immunoglobulin E; Immunology; Immunomodulators; Inflammation; Kinases; Lymphocytes; Medical care, Cost of; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolites; Neutrophils; Permeability; Pneumology/Respiratory System; Pollutants; Polyphenols; Proteins; Quercetin; Review; Signal transduction; Tumor necrosis factor-TNF; Allergy; Quercetin; Asthma
• ISSN: 1710-1492; 1710-1484; 1710-1492
• DOI: 10.1186/s13223-020-00434-0

Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Quercetin can regulate the Th1/Th2 stability, and decrease the antigen-specific IgE antibody releasing by B cells. Quercetin has a main role in anti-inflammatory and immunomodulatory function which makes it proper for the management of different diseases. Allergic diseases are a big concern and have high health care costs. In addition, the use of current therapies such as ß2-agonists and corticosteroids has been limited for long term use due to their numerous side effects. Since the effect of quercetin on allergic diseases has been widely studied, in the current article, we review the effect of quercetin on allergic diseases, such as allergic asthma, allergic rhinitis (AR), and atopic dermatitis (AD).