鞍区占位视力受损患者与视觉皮层相关的静息态fMRI研究

目的静息态功能磁共振成像探索鞍区占位视力受损患者引起的脑功能活动改变情况。方法筛选21例鞍区占位视力受损患者,并选择与之年龄和性别相匹配的健康对照者21名。计算ALFF、ReHo、FC值,然后采用双样本t检验统计学方法进行研究。结果与正常对照组相比,鞍区占位视力受损患者组双侧楔叶、左侧舌回、右侧SMA区域ALFF值降低,双侧豆状核ALFF值升高。双侧楔叶ReHo值降低,楔前叶、左侧岛叶皮层和左侧豆状核ReHo值升高,并且楔前叶和左侧岛叶皮层的ReHo值与常规磁共振手动测量的占位的左右直径存在明显正相关性。在功能连接结果中,高级视觉皮层与双侧楔叶、双侧顶上小叶、双侧颞上回、双侧缘上回、中央前回、...

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Published in影像诊断与介入放射学 Vol. 26; no. 4; pp. 296 - 301
Main Author 王忠艳 高培毅 隋滨滨
Format Journal Article
LanguageChinese
Published 首都医科大学附属北京中医医院放射科, 北京,100010%100050 北京,首都医科大学附属北京天坛医院放射科,磁共振成像脑信息学北京市重点实验室,北京市神经外科研究所 2017
Subjects
功能磁共振成像
静息态
鞍区肿瘤
Functional magnetic resonance imaging
Resting-state
Sellar tumors
功能磁共振成像
鞍区肿瘤
静息态
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ISSN1005-8001
DOI10.3969/j.issn.1005-8001.2017.04.007

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Summary:目的静息态功能磁共振成像探索鞍区占位视力受损患者引起的脑功能活动改变情况。方法筛选21例鞍区占位视力受损患者,并选择与之年龄和性别相匹配的健康对照者21名。计算ALFF、ReHo、FC值,然后采用双样本t检验统计学方法进行研究。结果与正常对照组相比,鞍区占位视力受损患者组双侧楔叶、左侧舌回、右侧SMA区域ALFF值降低,双侧豆状核ALFF值升高。双侧楔叶ReHo值降低,楔前叶、左侧岛叶皮层和左侧豆状核ReHo值升高,并且楔前叶和左侧岛叶皮层的ReHo值与常规磁共振手动测量的占位的左右直径存在明显正相关性。在功能连接结果中,高级视觉皮层与双侧楔叶、双侧顶上小叶、双侧颞上回、双侧缘上回、中央前回、中央后回及SMA存在功能连接减弱。结论鞍区占位视力受损患者存在视觉以及视觉以外相关脑区神经元活动异常。
Bibliography:44-1391/R
Objective To investigate how brain neural activity changes in visual deprivation of patients with sellar tumors.Methods Resting-state fMRI analysis was performed on 21 patients with sellar tumors and 21 sex-matched healthy volunteers. The low frequency amplitude（ALFF）, regional homogeneity（ReHo）, functional connectivity（FC） of patients and healthy controls were com-pared. Results Patients with sellar tumors exhibited significantly decreased ALFF in the bilateral cuneus, left lingual gyri and right supplementary motor area, increased ALFF in bilateral lentiform nuclei（ P 0.05, corrected by FDR）. Patients also showed decreased ReHo in the bilateral cuneus, increased ReHo in the precuneus, left insula, and left lentiform nucleus（ P 0.01, corrected by Alpha Sim）. The ReHo values in the precuneus（P〈0.05, R=0.423） and insula（P〈0.05, R=0.492） correlated with the right-left tumor diameters. The high-level visual cortex（-6,-80, 27） in patients showed decreased FC with bilateral cuneus, superior parietal lobul
ISSN:1005-8001
DOI:10.3969/j.issn.1005-8001.2017.04.007