Epigenetics in Cardiac Hypertrophy and Heart Failure

• Published in: JACC. Basic to translational science Vol. 4; no. 8; pp. 976 - 993
• Main Authors: Liu, Chia-Feng, Tang, W.H. Wilson
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2019; Elsevier
• Subjects: cardiac hypertrophy; Cardiovascular; epigenetics; heart failure; STATE-OF-THE-ART REVIEW; TMAO; heart failure; lnc-RNAs; epigenetics; HMT; PTMs; BET; HDM; PRC2; TAD; HAT; cardiac hypertrophy; HF; EZH2; HDAC; polycomb repressor complex 2; histone acetyltransferase; Enhancer of zeste homolog 2; histone demethylase; long ncRNAs; bromodomain; post-translational modifications; topologically associating domains; trimethylamine N-oxide; histone deacetylase; histone methyltransferase; TMAO, trimethylamine N-oxide; HDM, histone demethylase; lnc-RNAs, long ncRNAs; PTMs, post-translational modifications; HMT, histone methyltransferase; PRC2, polycomb repressor complex 2; HAT, histone acetyltransferase; BET, bromodomain; HF, heart failure; EZH2, Enhancer of zeste homolog 2; HDAC, histone deacetylase; TAD, topologically associating domains
• ISSN: 2452-302X; 2452-302X
• DOI: 10.1016/j.jacbts.2019.05.011

•Epigenetic mechanisms associated with the pathological process of cardiac hypertrophy and failure include DNA methylation, post-modification of histones, ATP-dependent chromatin conformation and remodeling, and non-coding RNAs.•Systemic- and cardiac-epigenetic mechanisms may both influence the disease processes of cardiac hypertrophy and failure.•Identifying vital epigenetic machinery in cardiac diseases may facilitate developing personalized therapy for HF. Heart failure (HF) is a complex syndrome affecting millions of people around the world. Over the past decade, the therapeutic potential of targeting epigenetic regulators in HF has been discussed extensively. Recent advances in next-generation sequencing techniques have contributed substantial progress in our understanding of the role of DNA methylation, post-translational modifications of histones, adenosine triphosphate (ATP)-dependent chromatin conformation and remodeling, and non-coding RNAs in HF pathophysiology. In this review, we summarize epigenomic studies on human and animal models in HF. [Display omitted]