Effects of acute psychosocial stress on source level EEG power and functional connectivity measures

• Published in: Scientific Reports Vol. 13; no. 1; pp. 8807 - 13
• Main Authors: Vanhollebeke, Gert, Kappen, Mitchel, De Raedt, Rudi, Baeken, Chris, van Mierlo, Pieter, Vanderhasselt, Marie-Anne
• Format: Journal Article
• Language: English
• Published: London Springer Science and Business Media LLC 31.05.2023; Nature Publishing Group UK; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 631/477; 692/617; Brain; Brain Mapping; CINGULATE CORTEX; Cortex (cingulate); Cortex (parietal); DISORDER; EEG; Electroencephalography; Gyrus Cinguli; Gyrus Cinguli - diagnostic imaging; HEART-RATE; Humanities and Social Sciences; Humans; Medicine; Medicine and Health Sciences; Multidisciplinary; NETWORK; Neural networks; PRECUNEUS; Q; R; RESPONSES; Science; Science (multidisciplinary); Sensors; Social interactions; SOCIAL REJECTION; Stress, Psychological; Temporal lobe; WORK
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-35808-y

The usage of EEG to uncover the influence of psychosocial stressors (PSSs) on neural activity has gained significant attention throughout recent years, but the results are often troubled by confounding stressor types. To investigate the effect of PSSs alone on neural activity, we employed a paradigm where participants are exposed to negative peer comparison as PSS, while other possible stressors are kept constant, and compared this with a condition where participants received neutral feedback. We analyzed commonly used sensor level EEG indices (frontal theta, alpha, and beta power) and further investigated whether source level power and functional connectivity (i.e., the temporal dependence between spatially seperated brain regions) measures, which have to our knowledge not yet been used, are more sensitive to PSSs than sensor level-derived EEG measures. Our results show that on sensor level, no significant frontal power changes are present (all p ’s > 0.16), indicating that sensor level frontal power measures are not sensitive enough to be affected by only PSSs. On source level, we find increased alpha power (indicative of decreased cortical activity) in the left- and right precuneus and right posterior cingulate cortex (all p ’s < 0.03) and increased functional connectivity between the left- and right precuneus ( p  < 0.001), indicating that acute, trial based PSSs lead to decreased precuneus/PCC activity, and possibly indicates a temporary disruption in the self-referential neural processes of an individual.