Interstitial lung abnormality evaluated by an automated quantification system: prevalence and progression rate

• Published in: Respiratory research Vol. 25; no. 1; pp. 78 - 10
• Main Authors: Oh, Ju Hyun, Kim, Grace Hyun J., Song, Jin Woo
• Format: Journal Article
• Language: English
• Published: London BioMed Central 06.02.2024; BioMed Central Ltd; Nature Publishing Group; BMC
• Subjects: Abnormalities; Age; Analysis; Automation; Blood; Body mass index; Body size; Care and treatment; Chest; Computed tomography; CT imaging; Diagnosis; Erythrocyte sedimentation rate; Erythrocytes; Fibrosis; Humans; Interstitial lung disease; Lung; Lung diseases, Interstitial; Lungs; Male; Medical examination; Medical imaging; Medical screening; Medicine; Medicine & Public Health; Methods; Middle Aged; Mortality; Performance evaluation; Pilot projects; Pneumology/Respiratory System; Prevalence; Prognosis; Quantitative analysis; Reproducibility; Retrospective Studies; Risk Factors; Software; Survival analysis; Tomography, X-Ray Computed - methods; South Korea; Prevalence; Prognosis; Interstitial lung disease; Mortality; Fibrosis
• ISSN: 1465-993X; 1465-9921; 1465-993X
• DOI: 10.1186/s12931-024-02715-3

Background Despite the importance of recognizing interstitial lung abnormalities, screening methods using computer-based quantitative analysis are not well developed, and studies on the subject with an Asian population are rare. We aimed to identify the prevalence and progression rate of interstitial lung abnormality evaluated by an automated quantification system in the Korean population. Methods A total of 2,890 healthy participants in a health screening program (mean age: 49 years, men: 79.5%) with serial chest computed tomography images obtained at least 5 years apart were included. Quantitative lung fibrosis scores were measured on the chest images by an automated quantification system. Interstitial lung abnormalities were defined as a score ≥ 3, and progression as any score increased above baseline. Results Interstitial lung abnormalities were identified in 251 participants (8.6%), who were older and had a higher body mass index. The prevalence increased with age. Quantification of the follow-up images (median interval: 6.5 years) showed that 23.5% (59/251) of participants initially diagnosed with interstitial lung abnormality exhibited progression, and 11% had developed abnormalities (290/2639). Older age, higher body mass index, and higher erythrocyte sedimentation rate were independent risk factors for progression or development. The interstitial lung abnormality group had worse survival on follow-up (5-year mortality: 3.4% vs. 1.5%; P  = 0.010). Conclusions Interstitial lung abnormality could be identified in one-tenth of the participants, and a quarter of them showed progression. Older age, higher body mass index and higher erythrocyte sedimentation rate increased the risk of development or progression of interstitial lung abnormality.