Parental age and developmental milestones: pilot study indicated a role in understanding ADHD severity in Indian probands

• Published in: BMC pediatrics Vol. 19; no. 1; pp. 117 - 8
• Main Authors: Maitra, Subhamita, Mukhopadhyay, Kanchan
• Format: Journal Article
• Language: English
• Published: London BioMed Central 22.04.2019; BioMed Central Ltd; Springer Nature B.V; BMC
• Subjects: ADHD; Adult; Age; Analysis; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - epidemiology; Attention Deficit Disorder with Hyperactivity - physiopathology; Attention deficit hyperactivity disorder; Behavior and development; Behavioral problem; Birth history; Birth order; Birth weight; Child; Children & youth; Datasets; Developmental milestone; DNA methylation; Etiology (Medicine); Female; Humans; Hyperactivity; Impulsive Behavior - physiology; Impulsivity; Inattention; India - epidemiology; Internal Medicine; Male; Medicine; Medicine & Public Health; Parenting; Parents; Pediatrics; Pilot Projects; Prevalence; Principal components analysis; Problem Behavior - psychology; Research Article; Risk Factors; Severity of Illness Index; Thyroid gland; Variables; India; ADHD; Impulsivity; Developmental milestone; Inattention; Birth history; Behavioral problem
• ISSN: 1471-2431; 1471-2431
• DOI: 10.1186/s12887-019-1483-x

Background In different ethnic groups, birth related factors have shown significant influence in the etiology of Attention deficit hyperactivity disorder (ADHD). Based on these interesting findings, we aimed to investigate association between different pre- and post natal variables and ADHD associated traits in Indian subjects. Methods ADHD Probands recruited based on the DSM-IV, were assessed by the Conner’s Parent Rating Scale for behavioral problem (BPr), inattention (IA), hyperactivity (HA) and ADHD index (AI). Impulsivity (Imp) was assessed by the Tsukuyama scale. Results Higher paternal (Std β = 0.23) and lower maternal (Std β = 0.21) age showed significant association with Imp of the probands. Higher paternal age also revealed association with BPr (Std β = 0.18). Age of onset was distinctly associated with AI (Std β < 0.16) while developmental delay was negatively correlated with BPr, Imp, IA and birth weight (r < − 0.13); also confirmed by Posthoc-ANOVA ( P  < 0.05). Conclusion We infer that parental age, developmental delay and birth related variables may have a cumulative effect on ADHD symptom severity.