Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance

• Published in: Journal for immunotherapy of cancer Vol. 6; no. 1; pp. 137 - 12
• Main Authors: Boyiadzis, Michael M., Dhodapkar, Madhav V., Brentjens, Renier J., Kochenderfer, James N., Neelapu, Sattva S., Maus, Marcela V., Porter, David L., Maloney, David G., Grupp, Stephan A., Mackall, Crystal L., June, Carl H., Bishop, Michael R.
• Format: Journal Article
• Language: English
• Published: London BioMed Central 04.12.2018; BioMed Central Ltd; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Animals; Antigens; Antigens, Neoplasm - immunology; Apoptosis; Axicabtagene ciloleucel; Blood diseases; Cancer; Cancer therapies; Care and treatment; Cellular therapy; Chemotherapy; Chimeric antigen receptor; Clinical Trials as Topic; Communication; Cytokines; Cytotoxicity; Design; FDA approval; Genetic Engineering; Hematologic Neoplasms - diagnosis; Hematologic Neoplasms - immunology; Hematologic Neoplasms - therapy; Humans; Immunology; Immunotherapy; Immunotherapy, Adoptive - adverse effects; Immunotherapy, Adoptive - methods; Leukemia; Lymphocytes; Lymphoma; Medicine; Medicine & Public Health; Oncology; Patients; Pediatrics; Peptides; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - metabolism; Receptors, Chimeric Antigen - genetics; Receptors, Chimeric Antigen - metabolism; Remission (Medicine); Review; Reviews; Signal transduction; T cell receptors; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tisagenlecleucel; Treatment Outcome; Chimeric antigen receptor; Lymphoma; Leukemia; Axicabtagene ciloleucel; Tisagenlecleucel
• ISSN: 2051-1426; 2051-1426
• DOI: 10.1186/s40425-018-0460-5

Chimeric Antigen Receptor (CAR) T cell therapies – adoptive T cell therapies that have been genetically engineered for a new antigen-specificity - have displayed significant success in treating patients with hematologic malignancies, leading to three recent US Food and Drug Administration approvals. Based on the promise generated from these successes, the field is rapidly evolving to include new disease indications and CAR designs, while simultaneously reviewing and optimizing toxicity and management protocols. As such, this review provides expert perspective on the significance and clinical considerations of CAR T cell therapies in order to provide timely information to clinicians about this revolutionary new therapeutic class.