The complement system in glioblastoma multiforme

• Published in: Acta neuropathologica communications Vol. 6; no. 1; pp. 91 - 12
• Main Authors: Bouwens van der Vlis, T. A. M., Kros, J. M., Mustafa, D. A. M., van Wijck, R. T. A., Ackermans, L., van Hagen, P. M., van der Spek, P. J.
• Format: Journal Article
• Language: English
• Published: London BioMed Central 12.09.2018; BioMed Central Ltd; BMC
• Subjects: Angiogenesis; Biomedical and Life Sciences; Biomedicine; Brain cancer; Glioma; Gliomas; Immune system; Immunotherapy; Inflammation; Metastasis; Neurology; Neurosciences; Pathology; Proteins; Review; Tumors; Glioma Stem-like Cells (GSC); Complement System Activation; C-X-C Motif Chemokine Receptor 4 (CXCR4); Myeloid-derived Suppressor Cells (MDSCs); Hematopoietic Stem/progenitor Cells (HSPCs)
• ISSN: 2051-5960; 2051-5960
• DOI: 10.1186/s40478-018-0591-4

The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.