Sonic vibration ameliorates inflammatory diseases via the up-regulation of IL-10

• Published in: Animal cells and systems Vol. 28; no. 1; pp. 161 - 170
• Main Authors: Ahn, Huijeong, Jung, Eui-Man, Cho, Min-Woo, Shin, Meoung-Geun, Choi, Jae-Yeong, Lee, Geun-Shik
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 31.12.2024; Taylor & Francis Ltd; Taylor & Francis Group; 한국통합생물학회
• Subjects: Animal models; animals; Blood circulation; Colitis; Cytokines; death; In vivo methods and tests; Inflammatory diseases; interelukin-10; Interleukin 10; Lethality; lipopolysaccharide; Lipopolysaccharides; Macrophages; pain; Peritoneal exudate cells; secretion; Signs and symptoms; Sine waves; Sonic vibration; therapeutics; Vibration; Vibration effects; Vibrations; 생물학; macrophages; colitis; Sonic vibration; interelukin-10; lipopolysaccharide
• ISSN: 1976-8354; 2151-2485; 2151-2485
• DOI: 10.1080/19768354.2024.2346598

Sonic vibration (SV), or vibroacoustic therapy, is applied to enhance local and systemic blood circulation and alleviate pain using low-frequency sine wave vibrations. However, there is limited scientific data on the mechanisms through which the benefits are achieved. In this study, we investigated the impact of SV on inflammatory responses by assessing cytokine secretion in both in vivo and in vitro models. After inducing inflammatory responses in mice and macrophages, we studied cytokine expression and the symptoms of inflammatory diseases in response to three frequencies (14, 45, or 90 Hz) of SV stimulation at 0.5 m/s 2 of amplitude. The results showed that SV at 90 Hz significantly increased interelukin-10 (IL-10) secretion in mice who were administered lipopolysaccharides (LPS) and increased the expression of IL-10 transcripts in peritoneal exudate cells and macrophages. Furthermore, SV at 90 Hz improved LPS-induced lethality and alleviated symptoms in a colitis model. In conclusion, this study scientifically proves the anti-inflammatory effects of vibration therapy through its ability to increase IL-10 expression.