Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis...

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Published in	Nature medicine Vol. 14; no. 5; pp. 507 - 509
Main Authors	Mendez, Ivar, Viñuela, Angel, Astradsson, Arnar, Mukhida, Karim, Hallett, Penelope, Robertson, Harold, Tierney, Travis, Holness, Renn, Dagher, Alain, Trojanowski, John Q, Isacson, Ole
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.05.2008 Nature Publishing Group
Subjects	Biomedical and Life Sciences Biomedicine Brain Tissue Transplantation - methods Brain Tissue Transplantation - pathology brief-communication Cancer Research Clinical outcomes Dopamine Fetal Tissue Transplantation - methods Fetal Tissue Transplantation - pathology Humans Immunohistochemistry Infectious Diseases Male Metabolic Diseases Middle Aged Molecular Medicine Neurons Neurons - pathology Neurophysiology Neurosciences Neurotransmitters Parkinson Disease - diagnostic imaging Parkinson Disease - therapy Parkinson's disease Pathology Phenols Positron-Emission Tomography Skin & tissue grafts Treatment Outcome Tyrosine 3-Monooxygenase
Online Access	Get full text
ISSN	1078-8956 1546-170X 1546-170X
DOI	10.1038/nm1752

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Abstract	Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
AbstractList	Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies. Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies. [PUBLICATION ABSTRACT] Postmortem analysis of five subjects with Parkinson’s disease9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies. Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
Audience	Academic
Author	Tierney, Travis Mukhida, Karim Hallett, Penelope Isacson, Ole Mendez, Ivar Astradsson, Arnar Viñuela, Angel Dagher, Alain Robertson, Harold Trojanowski, John Q Holness, Renn
AuthorAffiliation	2 Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA 4 Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson’s Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA 1 Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada 3 McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
AuthorAffiliation_xml	– name: 3 McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4, Canada – name: 1 Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada – name: 2 Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA – name: 4 Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson’s Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Author_xml	– sequence: 1 givenname: Ivar surname: Mendez fullname: Mendez, Ivar organization: Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, Dalhousie University and Queen Elizabeth II Health Sciences Centre – sequence: 2 givenname: Angel surname: Viñuela fullname: Viñuela, Angel organization: Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson's Disease Research Center of Excellence – sequence: 3 givenname: Arnar surname: Astradsson fullname: Astradsson, Arnar organization: Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson's Disease Research Center of Excellence – sequence: 4 givenname: Karim surname: Mukhida fullname: Mukhida, Karim organization: Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, Dalhousie University and Queen Elizabeth II Health Sciences Centre – sequence: 5 givenname: Penelope surname: Hallett fullname: Hallett, Penelope organization: Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson's Disease Research Center of Excellence – sequence: 6 givenname: Harold surname: Robertson fullname: Robertson, Harold organization: Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, Dalhousie University and Queen Elizabeth II Health Sciences Centre – sequence: 7 givenname: Travis surname: Tierney fullname: Tierney, Travis organization: Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson's Disease Research Center of Excellence – sequence: 8 givenname: Renn surname: Holness fullname: Holness, Renn organization: Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, Dalhousie University and Queen Elizabeth II Health Sciences Centre – sequence: 9 givenname: Alain surname: Dagher fullname: Dagher, Alain organization: McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre – sequence: 10 givenname: John Q surname: Trojanowski fullname: Trojanowski, John Q organization: Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson's Disease Research Center of Excellence – sequence: 11 givenname: Ole surname: Isacson fullname: Isacson, Ole email: isacson@hms.harvard.edu organization: Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson's Disease Research Center of Excellence
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18391961$$D View this record in MEDLINE/PubMed
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ContentType	Journal Article
Copyright	Springer Nature America, Inc. 2008 COPYRIGHT 2008 Nature Publishing Group Copyright Nature Publishing Group May 2008
Copyright_xml	– notice: Springer Nature America, Inc. 2008 – notice: COPYRIGHT 2008 Nature Publishing Group – notice: Copyright Nature Publishing Group May 2008
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 AUTHOR CONTRIBUTIONS These authors contributed equally to this work. I.M. and A.V. designed research, performed research, analyzed data and wrote the paper. A.A. and P.H. performed research, analyzed data and wrote the paper. K.M. analyzed data and wrote the paper. H.R., T.T., R.H. and A.D. performed research and analyzed data. J.Q.T. performed neuropathology staining, analyzed raw data, evaluated and interpreted data and wrote the paper. O.I. designed research, performed research, analyzed raw data, evaluated and interpreted data and wrote the paper.
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Snippet	Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts... Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts... Postmortem analysis of five subjects with Parkinson’s disease9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that...
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SubjectTerms	Biomedical and Life Sciences Biomedicine Brain Tissue Transplantation - methods Brain Tissue Transplantation - pathology brief-communication Cancer Research Clinical outcomes Dopamine Fetal Tissue Transplantation - methods Fetal Tissue Transplantation - pathology Humans Immunohistochemistry Infectious Diseases Male Metabolic Diseases Middle Aged Molecular Medicine Neurons Neurons - pathology Neurophysiology Neurosciences Neurotransmitters Parkinson Disease - diagnostic imaging Parkinson Disease - therapy Parkinson's disease Pathology Phenols Positron-Emission Tomography Skin & tissue grafts Treatment Outcome Tyrosine 3-Monooxygenase
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Title	Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
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