Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis...

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Bibliographic Details
Published in	Nature medicine Vol. 14; no. 5; pp. 507 - 509
Main Authors	Mendez, Ivar, Viñuela, Angel, Astradsson, Arnar, Mukhida, Karim, Hallett, Penelope, Robertson, Harold, Tierney, Travis, Holness, Renn, Dagher, Alain, Trojanowski, John Q, Isacson, Ole
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.05.2008 Nature Publishing Group
Subjects	Biomedical and Life Sciences Biomedicine Brain Tissue Transplantation - methods Brain Tissue Transplantation - pathology brief-communication Cancer Research Clinical outcomes Dopamine Fetal Tissue Transplantation - methods Fetal Tissue Transplantation - pathology Humans Immunohistochemistry Infectious Diseases Male Metabolic Diseases Middle Aged Molecular Medicine Neurons Neurons - pathology Neurophysiology Neurosciences Neurotransmitters Parkinson Disease - diagnostic imaging Parkinson Disease - therapy Parkinson's disease Pathology Phenols Positron-Emission Tomography Skin & tissue grafts Treatment Outcome Tyrosine 3-Monooxygenase
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ISSN	1078-8956 1546-170X 1546-170X
DOI	10.1038/nm1752

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Summary:	Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 AUTHOR CONTRIBUTIONS These authors contributed equally to this work. I.M. and A.V. designed research, performed research, analyzed data and wrote the paper. A.A. and P.H. performed research, analyzed data and wrote the paper. K.M. analyzed data and wrote the paper. H.R., T.T., R.H. and A.D. performed research and analyzed data. J.Q.T. performed neuropathology staining, analyzed raw data, evaluated and interpreted data and wrote the paper. O.I. designed research, performed research, analyzed raw data, evaluated and interpreted data and wrote the paper.
ISSN:	1078-8956 1546-170X 1546-170X
DOI:	10.1038/nm1752