双相障碍躁狂患者甲状腺激素与睡眠需要减少的相关性研究

目的探讨双相障碍躁狂患者血清甲状腺激素水平与睡眠需要减少之间的相关性。方法将122例双相障碍躁狂患者,按照是否伴发睡眠需要减少分为2组,比较2组人口学特征及甲状腺激素水平;采用Spearman法分别对2组患者甲状腺激素与临床症状的相关性进行分析;对睡眠需要减少的危险因素采用Logistic回归分析。结果与不伴睡眠需要减少的患者相比,伴睡眠需要减少的患者血清促甲状腺激素（TSH）水平较低[分别为（2.46±1.74）m U/L和（3.47±2.65）m U/L],甲状腺素（T4）水平较高[分别为（90.91±31.59）nmol/L和（76.80±38.55）nmol/L],差异均有统计学意义（...

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Published in上海交通大学学报（医学版） Vol. 36; no. 5; pp. 666 - 670
Main Author 黄佳 陈俊 王勇 洪武 苑成梅 汪作为 粟幼嵩 胡莺燕 曹岚 方贻儒
Format Journal Article
LanguageChinese
Published 上海交通大学医学院附属精神卫生中心心境障碍科,上海,200030%上海交通大学医学院附属精神卫生中心临床一科,上海,200030%上海虹口区精神卫生中心,上海,200083 2016
Subjects
双相障碍
甲状腺激素
睡眠需要减少
躁狂
躁狂
甲状腺激素
bipolar disorder
reduced need for sleep
thyroid hormone
双相障碍
睡眠需要减少
mania
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ISSN1674-8115
DOI10.3969/j.issn.1674-8115.2016.05.010

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Summary:目的探讨双相障碍躁狂患者血清甲状腺激素水平与睡眠需要减少之间的相关性。方法将122例双相障碍躁狂患者,按照是否伴发睡眠需要减少分为2组,比较2组人口学特征及甲状腺激素水平;采用Spearman法分别对2组患者甲状腺激素与临床症状的相关性进行分析;对睡眠需要减少的危险因素采用Logistic回归分析。结果与不伴睡眠需要减少的患者相比,伴睡眠需要减少的患者血清促甲状腺激素（TSH）水平较低[分别为（2.46±1.74）m U/L和（3.47±2.65）m U/L],甲状腺素（T4）水平较高[分别为（90.91±31.59）nmol/L和（76.80±38.55）nmol/L],差异均有统计学意义（P=0.046,P=0.048）。在伴有睡眠需要减少的患者中,甲状腺激素与精神运动性激越和过度担忧、社交活动增多和纠缠唠叨、使用精神活性物质呈正相关;不伴睡眠需要减少的患者,仅血清三碘甲状腺原氨酸水平（T3）与社交活动增多呈正相关（P=0.329）。Logistic回归分析结果显示,TSH、T4与睡眠需要减少存在相关性（OR=1.303,P=0.023;OR=0.986,P=0.045）。结论在双相障碍躁狂患者中,甲状腺激素水平可能是影响患者睡眠需要量和其他临床症状的潜在因素,睡眠需要减少与甲状腺激素的关系可能为改进临床治疗措施提供有益的信息。
Bibliography:bipolar disorder; mania; thyroid hormone; reduced need for sleep
Objective To explore the correlation between the serum thyroid hormone level and the need for reduced duration of sleep for patients with bipolar disorder（ BPD）. Methods O ne hundred and twenty two BPD patients were assigned to two groups on the basis of w hether the duration of sleep needed to be reduced.Demographic characteristics and thyroid horm one level were com pared between two groups. Spearm an＇s analysis was used to analyze the correlation between the thyroid hormone level and clinical symptoms for two groups.Logistic regression analysis was employed to assess risk factors for the duration of sleep needed to be reduced.Results C ompared with patients whose duration of sleep did not need to be reduced, patients whose duration of sleep needed to be reduced had a low er serum thyroid stimulating hormone（ TSH） level [（ 2. 46 ± 1. 74） mU / Lvs（ 3. 47 ± 2. 65） mU / L] and a higher tetraiodothyronine（ T4） level [（ 90. 91 ± 31. 59） nmol / L vs（
ISSN:1674-8115
DOI:10.3969/j.issn.1674-8115.2016.05.010