Association between number of vasopressors and mortality in COVID-19 patients

• Published in: American heart journal plus Vol. 34; p. 100324
• Main Authors: Sunnaa, Michael, Kerolos, Mina, Ruge, Max, Gill, Ahmad, Du-Fay-de-Lavallaz, Jeanne M., Rabin, Perry, Gomez, Joanne Michelle Dumlao, Williams, Kim, Rao, Anupama, Volgman, Annabelle Santos, Marinescu, Karolina, Suboc, Tisha Marie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2023; Elsevier
• Subjects: 60-day mortality; Cardiovascular; COVID-19; Intensive care unit; Research Paper; Shock; Vasopressors; COVID-19; Shock; Vasopressors; 60-day mortality; Intensive care unit
• ISSN: 2666-6022; 2666-6022
• DOI: 10.1016/j.ahjo.2023.100324

Study the clinical outcomes associated with the number of concomitant vasopressors used in critically ill COVID-19 patients. A single-center retrospective cohort study was conducted on patients admitted with COVID-19 to the intensive care unit (ICU) between March and October 2020. Rush University Medical Center, United States. Adult patients at least 18 years old with COVID-19 with continuous infusion of any vasopressors were included. 60-day mortality in COVID-19 patients by the number of concurrent vasopressors received. A total of 637 patients met our inclusion criteria, of whom 338 (53.1 %) required the support of at least one vasopressor. When compared to patients with no vasopressor requirement, those who required 1 vasopressor (V1) (adjusted odds ratio [aOR] 3.27, 95 % confidence interval (CI) 1.86–5.79, p < 0.01) (n = 137), 2 vasopressors (V2) (aOR 4.71, 95 % CI 2.54–8.77, p < 0.01) (n = 86), 3 vasopressors (V3) (aOR 26.2, 95 % CI 13.35–53.74 p < 0.01) (n = 74), and 4 or 5 vasopressors(V4–5) (aOR 106.38, 95 % CI 39.17–349.93, p < 0.01) (n = 41) were at increased risk of 60-day mortality. In-hospital mortality for patients who received no vasopressors was 6.7 %, 22.6 % for V1, 27.9 % for V2, 62.2 % for V3, and 78 % for V4-V5. Critically ill patients with COVID-19 requiring vasopressors were associated with significantly higher 60-day mortality.