宫颈上皮内瘤变诊治的相关研究进展

宫颈上皮内瘤变（CIN）是与宫颈癌密切相关的癌前病变。随着宫颈癌生物学研究的进展和筛查技术的进步,宫颈癌的筛查目标已转变为早期检出高级别CIN并行阻断性治疗。在CIN治疗策略的原则中,首要目的应是预防宫颈癌的发生。目前CIN的诊断仍依靠宫颈细胞学、阴道镜与组织病理学这三阶梯技术（“three step”technique）。治疗方面,推荐期待治疗作为CINⅠ女性的标准治疗。对于CINⅡ与CINⅢ,宫颈环形电切术（LEEP）和激光锥切是推荐的治疗方法。术后主要通过细胞学、人乳头瘤病毒（HPV）检测对低至中度疾病残留及复发风险患者进行随访,对高度疾病残留及复发风险患者,推荐阴道镜随诊。现拟从CIN...

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Bibliographic Details
Published in国际妇产科学杂志 Vol. 43; no. 4; pp. 436 - 441
Main Author 陈敏 颜建英
Format Journal Article
LanguageChinese
Published 350001 福州,福建省妇幼保健院妇产科,福建医科大学教学医院 2016
Subjects
乳头状瘤病毒科
宫颈上皮内瘤样病变
宫颈肿瘤
治疗
治疗
Therapy
宫颈上皮内瘤样病变
Cervical intraepithelial neoplasia
乳头状瘤病毒科
Uterine cervical neoplasms
Papillomaviridae
宫颈肿瘤
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ISSN1674-1870

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Summary:宫颈上皮内瘤变（CIN）是与宫颈癌密切相关的癌前病变。随着宫颈癌生物学研究的进展和筛查技术的进步,宫颈癌的筛查目标已转变为早期检出高级别CIN并行阻断性治疗。在CIN治疗策略的原则中,首要目的应是预防宫颈癌的发生。目前CIN的诊断仍依靠宫颈细胞学、阴道镜与组织病理学这三阶梯技术（“three step”technique）。治疗方面,推荐期待治疗作为CINⅠ女性的标准治疗。对于CINⅡ与CINⅢ,宫颈环形电切术（LEEP）和激光锥切是推荐的治疗方法。术后主要通过细胞学、人乳头瘤病毒（HPV）检测对低至中度疾病残留及复发风险患者进行随访,对高度疾病残留及复发风险患者,推荐阴道镜随诊。现拟从CIN的诊断、转归、治疗、CIN合并妊娠、CIN治疗后对妊娠结局的影响以及随访等方面进行综述。
Bibliography:12-1399/R
Cervical intraepithelial neoplasia （CIN） is recognized as a kind of precursor lesion associated with cervicalcancer. With the great progresses of cervical cancer biology research and screening techniques, early detection and treatment ofhigh grade CIN has become the goal of prevention of cervical cancer. The major ethical and medical aim of all managementoptions for CIN is the prevention of cervical cancer. To date, the ＂three-step＂ technique is still the primary way to detect anddiagnose of CIN. For management of CIN, observational management was recommended for women with CIN I , whereastreatment of CIN II and CIN IH should be excisional. Both loop electrosurgical excision procedure （LEEP） and laser conisationare accepted standard treatments for these patients. After treatment, cytology and human papillomavirus （HPV） testing are thebest post-treatment monitoring for patients with low risk of tumor residue and recurrence, whereas colposcopy is recommendedfor patients with high risk of tumor residue
ISSN:1674-1870