Silicone breast implant modification review: overcoming capsular contracture

• Published in: Biomaterials research Vol. 22; no. 1; pp. 37 - 9
• Main Authors: Shin, Byung Ho, Kim, Byung Hwi, Kim, Sujin, Lee, Kangwon, Choy, Young Bin, Heo, Chan Yeong
• Format: Journal Article
• Language: English
• Published: London BioMed Central 20.12.2018; BioMed Central Ltd; American Association for the Advancement of Science (AAAS); 한국생체재료학회
• Subjects: Adsorption; Analysis; Antibiotics; Antiinflammatory agents; Asthma; Biomaterials; Biomedical materials; Breast implants; Capsular contracture; Chemistry and Materials Science; Collagen; Complications and side effects; Cytokines; Fibroblasts; Fibrosis; Foreign body reaction; Growth factors; Immunosuppressive agents; Inflammation; Materials Science; Medical silicones; Modification; Physiology; Plastic surgery; Properties; Proteins; Review; Reviews; Silicone implant; Silicones; Topography; Toxicity; Transplantation; Transplants & implants; 의공학; Modification; Silicone implant; Capsular contracture; Inflammation; Foreign body reaction; Fibrosis
• ISSN: 2055-7124; 1226-4601; 2055-7124
• DOI: 10.1186/s40824-018-0147-5

Background Silicone implants are biomaterials that are frequently used in the medical industry due to their physiological inertness and low toxicity. However, capsular contracture remains a concern in long-term transplantation. To date, several studies have been conducted to overcome this problem. This review summarizes and explores these trends. Main body First, we examined the overall foreign body response from initial inflammation to fibrosis capsule formation in detail and introduced various studies to overcome capsular contracture. Secondly, we introduced that the main research approaches are to inhibit fibrosis with anti-inflammatory drugs or antibiotics, to control the topography of the surface of silicone implants, and to administer plasma treatment. Each study examined aspects of the various mechanisms by which capsular contracture could occur, and addressed the effects of inhibiting fibrosis. Conclusion This review introduces various silicone surface modification methods to date and examines their limitations. This review will help identify new directions in inhibiting the fibrosis of silicone implants.