子宫内膜异位症患者治疗后在位子宫内膜的变化
目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA,基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化,证实其参与了EMs的发生和发展。方法：检测EMs患者治疗前后和健康对照组的IL-8 mRNA,MMP-9和VEGF蛋白的表达。结果：EMs组治疗前在位内膜IL-8 mRNA的表达较对照组高,治疗后IL-8 mRNA的表达较治疗前下降（均P〈0.05）。EMs组治疗前MMP-9和VEGF阳性表达率高于对照组（P〈0.05）;EMs组治疗后的MMP-9和VEGF阳性表达率低于治疗前（P〈0.05）。治疗前IL-8 mRNA、MMP-...
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| Published in | 国际妇产科学杂志 Vol. 43; no. 2; pp. 210 - 213 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
518020,广东省深圳市人民医院妇科
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-1870 |
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| Abstract | 目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA,基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化,证实其参与了EMs的发生和发展。方法：检测EMs患者治疗前后和健康对照组的IL-8 mRNA,MMP-9和VEGF蛋白的表达。结果：EMs组治疗前在位内膜IL-8 mRNA的表达较对照组高,治疗后IL-8 mRNA的表达较治疗前下降（均P〈0.05）。EMs组治疗前MMP-9和VEGF阳性表达率高于对照组（P〈0.05）;EMs组治疗后的MMP-9和VEGF阳性表达率低于治疗前（P〈0.05）。治疗前IL-8 mRNA、MMP-9蛋白与VEGF蛋白表达呈正相关（rs分别为0.842,0.851,均P〈0.05）。结论：手术彻底切除EMs病灶联合药物治疗可以改善EMs患者在位内膜的微环境,延迟复发。在位内膜的IL-8、MMP-9和VEGF在EMs的发生、发展中具有协同作用。 |
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| AbstractList | 目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA,基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化,证实其参与了EMs的发生和发展。方法：检测EMs患者治疗前后和健康对照组的IL-8 mRNA,MMP-9和VEGF蛋白的表达。结果：EMs组治疗前在位内膜IL-8 mRNA的表达较对照组高,治疗后IL-8 mRNA的表达较治疗前下降（均P〈0.05）。EMs组治疗前MMP-9和VEGF阳性表达率高于对照组（P〈0.05）;EMs组治疗后的MMP-9和VEGF阳性表达率低于治疗前（P〈0.05）。治疗前IL-8 mRNA、MMP-9蛋白与VEGF蛋白表达呈正相关（rs分别为0.842,0.851,均P〈0.05）。结论：手术彻底切除EMs病灶联合药物治疗可以改善EMs患者在位内膜的微环境,延迟复发。在位内膜的IL-8、MMP-9和VEGF在EMs的发生、发展中具有协同作用。 目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA，基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化，证实其参与了EMs的发生和发展。方法：检测EMs患者治疗前后和健康对照组的IL-8 mRNA，MMP-9和VEGF蛋白的表达。结果：EMs组治疗前在位内膜IL-8 mRNA的表达较对照组高，治疗后IL-8 mRNA的表达较治疗前下降（均P＜0.05）。EMs组治疗前MMP-9和VEGF阳性表达率高于对照组（P＜0.05）；EMs组治疗后的MMP-9和VEGF阳性表达率低于治疗前（P＜0.05）。治疗前IL-8 mRNA、MMP-9蛋白与VEGF蛋白表达呈正相关（rs分别为0.842，0.851，均P＜0.05）。结论：手术彻底切除EMs病灶联合药物治疗可以改善EMs患者在位内膜的微环境，延迟复发。在位内膜的IL-8、MMP-9和VEGF在EMs的发生、发展中具有协同作用。 |
| Abstract_FL | Objective:To study the expression changes of interleukin- 8 (IL- 8) mRNA, matrix metalloproteinase 9 (MMP-9) and vascular endothelial growth factor (VEGF) in eutopic endometrium of patients with endometriosis (EMs), and to confirm that it is involved in the occurrence and development of EMs. Methods:IL-8 mRNA, MMP-9 and VEGF protein expression in eutopic endometrium of EMs patients before and after treatment and the healthy control group were detected. Results:The expression of IL-8 mRNA in EMs group before treated was higher than that in control group, and the expression of IL-8 mRNA was decreased after treatment (both P<0.05). Positive expression rate of MMP-9 and VEGF protein in endometriosis patients before treated were higher than that of the control group and the patients after treatment (P<0.05). IL-8 mRNA and MMP-9 protein expression and VEGF protein expression existed positive correlation (rs=0.842, 0.851, all P<0.05). Conclusions:Complete surgical excision of endometriosis lesions combined with drug therapy can improve the microenvironment of endometriosis and to delay its recurrence. IL-8, MMP-9 and VEGF had synergistic effect in endometriosis occurrence and development. |
| Author | 黄丽霞 马利国 |
| AuthorAffiliation | 广东省深圳市人民医院妇科,518020 |
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| Author_FL | HUANG Li-xia MA Li-guo |
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| DocumentTitleAlternate | Biological Effects of Ectopic Endometrium after Treatment on the Endometrium of the Uterus |
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| EndPage | 213 |
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| Keywords | 子宫内膜异位症 Matrix metalloproteinase 9 白细胞介素8 子宫内膜 Endometriosis 血管内皮生长因子类 基质金属蛋白酶9 Interleukin-8 Vascular endothelial growth factor Endometrium |
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| Notes | 12-1399/R HUANG Li-xia,MA Li-guo. （Department of Gynaecology, Shenzhen People＇s Hospital, Shenzhen 518020, Guangdong Province, China） Endometriosis; Endometrium; Interleukin-8; Matrix metalloproteinase 9; Vascular endothelial growth factor Objective：To study the expression changes of interleukin- 8（ IL-8） mRNA, matrix metalloproteinase 9（MMP-9） and vascular endothelial growth factor（VEGF） in eutopic endometrium of patients with endometriosis（EMs）, and to confirm that it is involved in the occurrence and development of EMs. Methods：IL-8 mRNA, MMP-9 and VEGF protein expression in eutopic endometrium of EMs patients before and after treatment and the healthy control group were detected.Results：The expression of IL-8 mRNA in EMs group before treated was higher than that in control group, and the expression of IL-8 mRNA was decreased after treatment（both P〈0.05）. Positive expression rate of MMP-9 and VEGF protein in endometriosis patients before treated were higher than that of the control group and the patients afte |
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| PublicationTitle | 国际妇产科学杂志 |
| PublicationTitleAlternate | Foreign Medical Sciences（Obstet Gynecol Fascicle） |
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| Publisher | 518020,广东省深圳市人民医院妇科 |
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| Snippet | 目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA,基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化,证实其参与了EMs... 目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA，基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化，证实其参与... |
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| SubjectTerms | 基质金属蛋白酶9 子宫内膜 子宫内膜异位症 白细胞介素8 血管内皮生长因子类 |
| Title | 子宫内膜异位症患者治疗后在位子宫内膜的变化 |
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