子宫内膜异位症患者治疗后在位子宫内膜的变化

目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA,基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化,证实其参与了EMs的发生和发展。方法：检测EMs患者治疗前后和健康对照组的IL-8 mRNA,MMP-9和VEGF蛋白的表达。结果：EMs组治疗前在位内膜IL-8 mRNA的表达较对照组高,治疗后IL-8 mRNA的表达较治疗前下降（均P〈0.05）。EMs组治疗前MMP-9和VEGF阳性表达率高于对照组（P〈0.05）;EMs组治疗后的MMP-9和VEGF阳性表达率低于治疗前（P〈0.05）。治疗前IL-8 mRNA、MMP-...

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Bibliographic Details
Published in国际妇产科学杂志 Vol. 43; no. 2; pp. 210 - 213
Main Author 黄丽霞 马利国
Format Journal Article
LanguageChinese
Published 518020,广东省深圳市人民医院妇科 2016
Subjects
基质金属蛋白酶9
子宫内膜
子宫内膜异位症
白细胞介素8
血管内皮生长因子类
子宫内膜异位症
Matrix metalloproteinase 9
白细胞介素8
子宫内膜
Endometriosis
血管内皮生长因子类
基质金属蛋白酶9
Interleukin-8
Vascular endothelial growth factor
Endometrium
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ISSN1674-1870

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Summary:目的：研究子宫内膜异位症（EMs）患者常规治疗后在位内膜的白细胞介素8（IL-8）mRNA,基质金属蛋白酶9（MMP-9）和血管内皮生长因子（VEGF）蛋白的表达变化,证实其参与了EMs的发生和发展。方法：检测EMs患者治疗前后和健康对照组的IL-8 mRNA,MMP-9和VEGF蛋白的表达。结果：EMs组治疗前在位内膜IL-8 mRNA的表达较对照组高,治疗后IL-8 mRNA的表达较治疗前下降（均P〈0.05）。EMs组治疗前MMP-9和VEGF阳性表达率高于对照组（P〈0.05）;EMs组治疗后的MMP-9和VEGF阳性表达率低于治疗前（P〈0.05）。治疗前IL-8 mRNA、MMP-9蛋白与VEGF蛋白表达呈正相关（rs分别为0.842,0.851,均P〈0.05）。结论：手术彻底切除EMs病灶联合药物治疗可以改善EMs患者在位内膜的微环境,延迟复发。在位内膜的IL-8、MMP-9和VEGF在EMs的发生、发展中具有协同作用。
Bibliography:12-1399/R
HUANG Li-xia,MA Li-guo. （Department of Gynaecology, Shenzhen People＇s Hospital, Shenzhen 518020, Guangdong Province, China）
Endometriosis; Endometrium; Interleukin-8; Matrix metalloproteinase 9; Vascular endothelial growth factor
Objective：To study the expression changes of interleukin- 8（ IL-8） mRNA, matrix metalloproteinase 9（MMP-9） and vascular endothelial growth factor（VEGF） in eutopic endometrium of patients with endometriosis（EMs）, and to confirm that it is involved in the occurrence and development of EMs. Methods：IL-8 mRNA, MMP-9 and VEGF protein expression in eutopic endometrium of EMs patients before and after treatment and the healthy control group were detected.Results：The expression of IL-8 mRNA in EMs group before treated was higher than that in control group, and the expression of IL-8 mRNA was decreased after treatment（both P〈0.05）. Positive expression rate of MMP-9 and VEGF protein in endometriosis patients before treated were higher than that of the control group and the patients afte
ISSN:1674-1870