Cognitive training in neurodegenerative diseases： a way to boost neuroprotective molecules

• Published in: Neural regeneration research Vol. 10; no. 11; pp. 1754 - 1755
• Main Authors: Angelucci, Francesco, Caltagirone, Carlo, Costa, Alberto
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.11.2015; Medknow Publications & Media Pvt. Ltd; Niccolò Cusano University, Rome, Italy; Department of Systemic Medicine, Rome University Tor Vergata, Rome, Italy%IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy; IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy%IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Animal cognition; Blood-brain barrier; Brain-derived neurotrophic factor; Care and treatment; Cognitive therapy; Exercise; Growth factors; Health aspects; Laboratory animals; Neurodegeneration; Neurodegenerative diseases; Physical fitness; Proteins; 中枢神经系统; 分子; 生长因子; 病理模型; 神经保护作用; 神经营养因子; 神经退行性疾病; 训练; China; @@
• ISSN: 1673-5374; 1876-7958; 1876-7958
• DOI: 10.4103/1673-5374.169608

Neurotrophins,and growth factors in general,are proteins which exert many actions in central nervous system neurons.Neurotrophins promote the survival and neuronal function of neurons and exert neuroprotective effects in pathological models of neurodegenerative diseases.In humans several clinical trials based on the use of these proteins have been carried out. Among them, it is worth to mention gene ther- apy especially in Parkinson＇s disease （PD） （Kordower and Bjorklund, 2013）, and a series of experiments using vectors capable of carrying neurotrophins in the selected target re- gion where they can exert their beneficial action （Ghosh et al., 2014）.