Self-reported sleep disturbance is associated with Alzheimer's disease risk in men

• Published in: Alzheimer's & dementia Vol. 11; no. 9; pp. 1090 - 1097
• Main Authors: Benedict, Christian, Byberg, Liisa, Cedernaes, Jonathan, Hogenkamp, Pleunie S, Giedratis, Vilmantas, Kilander, Lena, Lind, Lars, Lannfelt, Lars, Schiöth, Helgi B
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015; Elsevier B.V
• Subjects: Aged; Aged, 80 and over; All-cause dementia; Alzheimer Disease - blood; Alzheimer Disease - epidemiology; Alzheimer's disease; Amyloid beta-Peptides - blood; Humans; Logistic Models; Longitudinal Studies; Longitudinal study; Male; Middle Aged; Neurology; Peptide Fragments - blood; Risk; Self Report; Sleep; Sleep Wake Disorders - blood; Sleep Wake Disorders - epidemiology; Sweden - epidemiology; Sweden; Sleep; Alzheimer's disease; All-cause dementia; Longitudinal study
• ISSN: 1552-5260; 1552-5279; 1552-5279
• DOI: 10.1016/j.jalz.2014.08.104

Abstract Objective To study the association between self-reported sleep disturbances and dementia risk. Methods Self-reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history between ages 50 and 90 years. In addition, plasma levels of β-amyloid (Aβ) peptides 1–40 and 1–42 were measured at ages 70, 77, and 82 years. Results Cox regression demonstrated that men with self-reported sleep disturbances had a higher risk of developing dementia (+33%) and Alzheimer's disease (AD, +51%) than men without self-reported sleep disturbances (both P  < .05). Binary logistic regression showed the increased risk for both dementia (+114%) and AD (+192%) were highest when sleep disturbance was reported at age 70 years (both P  < .001). No group differences were found in Aβ levels. Conclusion Improving sleep quality may help reduce the neurodegenerative risk in older men.