RAS抑制剂的骨生物学作用研究进展
近来研究显示,骨组织、骨细胞存在肾素-血管紧张素系统（RAS）组分。功能性研究发现骨骼RAS参与了骨质疏松症的发生、发展,充分揭示了骨骼RAS在骨代谢中的重要作用。本文综述了血管紧张素转化酶抑制剂、血管紧张素受体拮抗剂对骨代谢的改善作用与不利影响。本文有助于更好地理解组织RAS在调控骨健康中的生物学作用,为临床应用RAS抑制剂治疗高血压或糖尿病并发症患者的用药具有指导意义。...
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| Published in | 中国骨质疏松杂志 Vol. 23; no. 8; pp. 1117 - 1120 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
上海中医药大学脊柱病研究所,上海200032
2017
上海中医药大学康复医学院,上海201203 上海中医药大学脊柱病研究所,上海200032%上海理工大学医疗器械与食品学院,上海,200093%上海中医药大学附属龙华医院,上海200032 上海中医药大学附属龙华医院,上海200032 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-7108 |
| DOI | 10.3969/j.issn.1006-7108.2017.08.029 |
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| Summary: | 近来研究显示,骨组织、骨细胞存在肾素-血管紧张素系统（RAS）组分。功能性研究发现骨骼RAS参与了骨质疏松症的发生、发展,充分揭示了骨骼RAS在骨代谢中的重要作用。本文综述了血管紧张素转化酶抑制剂、血管紧张素受体拮抗剂对骨代谢的改善作用与不利影响。本文有助于更好地理解组织RAS在调控骨健康中的生物学作用,为临床应用RAS抑制剂治疗高血压或糖尿病并发症患者的用药具有指导意义。 |
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| Bibliography: | SHA Nannan1,2 , LI Xiaoli3, WANG Yongjun1,2,4 , ZHANG Yan1,2 （1. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032 2. Spine Disease Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200032 3. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093 4. School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203） 11-3701/R Recent studies have revealed the existence of renin-angiotensin system（ RAS） components in bone tissue and bone cells. Functional studies demonstrated the involvement of skeletal RAS in the occurrence and development of osteoporosis,suggesting the important roles of skeletal RAS on bone metabolism. In this reviewwe summarized the beneficial and detrimental effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on bone metabolism. The information from this reviewwill be valuable for the better u |
| ISSN: | 1006-7108 |
| DOI: | 10.3969/j.issn.1006-7108.2017.08.029 |