金天格胶囊在预防绝经后女性骨质疏松性骨折中的作用

目的观察金天格胶囊在治疗绝经后女性骨质疏松的疗效,判断其预防骨折发生的概率。方法选取绝经后骨质疏松女性238名,随机分为4组,第1组：金天格59例,第2组：钙尔奇D＋金天格58例,第3组：钙尔奇D＋金天格＋阿仑膦酸钠63例,第4组：钙尔奇D＋阿仑膦酸钠58例;服药剂量：金天格1.2mg,tid;钙尔奇D 600mg qd;福善美70mg qw。分别在服药前、服药后3、6个月检测骨密度（bone mineral densities,BMD）、血清1型原胶原N-端前肽（PINP）和1型胶原交联C-末端肽（CTX）。结果各组骨密度无明显变化（P〉0.05）;服药3个月,4组的PINP分别下降了18....

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Bibliographic Details
Published in中国骨质疏松杂志 Vol. 21; no. 12; pp. 1498 - 1500
Main Author 甘强 谭祖建 周明全 胡维
Format Journal Article
LanguageChinese
Published 重庆市中山医院骨科中心,重庆,400013 2015
Subjects
金天格胶囊
骨密度
骨质疏松
骨转化指标
骨质疏松
Osteoporosis
Jintiange capsule
金天格胶囊
骨密度
Bone mineral density
骨转化指标
Bone turnover markers
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ISSN1006-7108
DOI10.3969/j.issn.1006-7108.2015.12.018

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Summary:目的观察金天格胶囊在治疗绝经后女性骨质疏松的疗效,判断其预防骨折发生的概率。方法选取绝经后骨质疏松女性238名,随机分为4组,第1组：金天格59例,第2组：钙尔奇D＋金天格58例,第3组：钙尔奇D＋金天格＋阿仑膦酸钠63例,第4组：钙尔奇D＋阿仑膦酸钠58例;服药剂量：金天格1.2mg,tid;钙尔奇D 600mg qd;福善美70mg qw。分别在服药前、服药后3、6个月检测骨密度（bone mineral densities,BMD）、血清1型原胶原N-端前肽（PINP）和1型胶原交联C-末端肽（CTX）。结果各组骨密度无明显变化（P〉0.05）;服药3个月,4组的PINP分别下降了18.2%、22.3%、62.3%、55.8%,CTX分别下降了24.3%、29.7%、68.7%、57.8%;服药6个月,4组的PINP分别下降了19.4%、23.6%、63.5%、62%,CTX分别下降了28.1%、28.3%、69.9%、64.5%。结论金天格胶囊可以明显降低骨转化指标,能有效辅助治疗骨质疏松和预防骨折的发生。
Bibliography:Osteoporosis; Jintiange capsule; Bone turnover markers; Bone mineral density
Objective To observetheefficacy of Jintiangecapsuleon thetreatment of osteoporosis and to judgetheprobability of osteoporotic fractureprevention in postmenopausal women. Methods Two hundred and thirty-eight postmenopausal women with osteoporosis wereselected and randomly divided into 4 groups,Group one（ Jintiangecapsulegroup,n = 59）,Group two（ calcium and Jintiangecapsulegroup,n = 58）,Group three（ calcium and Jintiangecapsuleand bisphosphonategroup,n = 63）,and Group four（ calcium and bisphosphonategroup,n = 58）. Thedosageof thedrugs was 1. 2mg of Jintiangecapsule,tid,600 mg of calcium,qd,and 70 mg of bisphosphonates,qw. Bonemineral densities（ BMD）,serum procollagen typeI amino-terminal propeptide（ PINP）,and serum C-terminal cross-linked telopeptides of typeI collagen（ CTX） weredetected beforeand after 3months and 6 months of thetreatment,respectively. Results BMD was not obviously changed in each group（ P〉0. 05）. After 3months of trea
ISSN:1006-7108
DOI:10.3969/j.issn.1006-7108.2015.12.018