Magnetic Guidance of Ferro-colloid-entrapped Emulsion for Site-specific Drug Delivery

Magnetic guidance of magnetic emulsions with site specificity was investigated in vitro and in vivo. The emulsions consisted of ethyl oleate-based magnetic fluid as the oily dispersed phase and 1% casein solution as the aqueous continuous phase. The magnetic emulsion was characterized in vitro for m...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 31; no. 1; pp. 279 - 285
Main Authors MORIMOTO, YASUNORI, SUGIBAYASHI, KENJI, AKIMOTO, MASAYUKI
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1983
Japan Science and Technology Agency
Subjects
Antineoplastic Agents - administration & dosage
cancer chemotherapy
Colloids
Emulsions
Humans
Iron
Magnetics
Organ Specificity
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.31.279

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Summary:Magnetic guidance of magnetic emulsions with site specificity was investigated in vitro and in vivo. The emulsions consisted of ethyl oleate-based magnetic fluid as the oily dispersed phase and 1% casein solution as the aqueous continuous phase. The magnetic emulsion was characterized in vitro for magnetic responsiveness by using a constant flow apparatus, and its high retention by a magnetic field was confirmed. Ethyl oleate in the magnetic emulsion was labelled with 14C-palmitic acid and a selective localization of the magnetic emulsion at a predetermined site (lungs) by application of an electromagnet to the lungs was demonstrated. Such preferential localization by magnetic means suggested that this new carrier system can provide a highly specific delivery system for chemotherapeutic agents in cancer chemotherapy.
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.31.279