人乳牙牙髓干细胞在干细胞治疗中的应用

乳牙牙髓干细胞（SHED）是牙源性干细胞的一种，属外胚间充质干细胞。作为一种理想的干细胞来源，SHED在干细胞治疗中有良好的应用前景。本文阐述了SHED的生物学特征及其在干细胞治疗中的优势，探讨了SHED在组织再生和修复中发挥的多向分化潜能、细胞分泌功能和免疫调节功能等方面的功能作用。此外，本文还介绍了SHED在各系统、器官疾病治疗中的临床应用，重点阐述了用SHED进行干细胞移植在牙髓一牙本质再生、颌骨再生、神经系统疾病治疗和免疫系统疾病治疗方面的研究进展。...

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Published in华西口腔医学杂志 Vol. 35; no. 5; pp. 533 - 537
Main Author 李晓霞 方滕姣子 余湜 赵玉呜 葛立宏
Format Journal Article
LanguageChinese
Published 北京大学口腔医学院·口腔医院儿童口腔科,北京 100081 2017
Subjects
临床应用
人乳牙牙髓干细胞
干细胞治疗
人乳牙牙髓干细胞
临床应用
stem cells from human exfoliated deciduous teeth
clinical applications
stem cell therapy
干细胞治疗
Online AccessGet full text
ISSN1000-1182
DOI10.7518/hxkq.2017.05.017

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Summary:乳牙牙髓干细胞（SHED）是牙源性干细胞的一种，属外胚间充质干细胞。作为一种理想的干细胞来源，SHED在干细胞治疗中有良好的应用前景。本文阐述了SHED的生物学特征及其在干细胞治疗中的优势，探讨了SHED在组织再生和修复中发挥的多向分化潜能、细胞分泌功能和免疫调节功能等方面的功能作用。此外，本文还介绍了SHED在各系统、器官疾病治疗中的临床应用，重点阐述了用SHED进行干细胞移植在牙髓一牙本质再生、颌骨再生、神经系统疾病治疗和免疫系统疾病治疗方面的研究进展。
Bibliography:51-1169/R
Stem cells from human exfoliated deciduous teeth （SHED） are one category of dental stem cells. They belong to ectodermal mesenchymal stem cells. As an ideal stem cell source, SHED possess great potential in stem cell therapy. This review demonstrates the biological characteristics and advantages of SHED in stem cell therapy and discusses its muItiple functions in tissue regeneration and repair, including multiple differentiation potentiality, cell secretion of cytokines, and immunomodulatory ability. Furthermore, this article introduces the main findings regarding the potential clinical applications of SHED to a variety of diseases. This article demonstrates research progress in dentin-pulp regeneration, maxillofacial bone regeneration, and treatment of nervous system and immune system diseases with SHED for stem cell transplantation.
stem cells from human exfoliated deciduous teeth; stem cell therapy; clinical applications
Li Xiaoxia, Fangteng Jiaozi, Yu Shi, Zhao Yuming, Ge Lihong. （Dept. of Pediatri
ISSN:1000-1182
DOI:10.7518/hxkq.2017.05.017