大脑脚间核脑深部电刺激改善帕金森病冻结步态的效果
目的探讨大脑脚间核脑深部电刺激对帕金森病冻结步态的改善效果。方法采用大脑脚间核脑深部电刺激（DBS）术治疗3例药物难治性冻结步态帕金森病患者。其中2例患者采用双侧大脑脚间核DBS,1例患者采用单侧大脑脚间核联合对侧丘脑底核DBS。采用UPDRSⅢ（27-30项）对患者的轴线症状进行评分,评估效果。结果术后2例双侧DBS术的患者改善率为63.6%和66.7%;单侧DBS术患者的改善率为57.1%。3例患者术后无明显并发症。结论大脑脚间核DBS术对药物难治性帕金森病冻结步态是一种安全有效的治疗方式。...
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| Published in | 临床神经外科杂志 Vol. 14; no. 5; pp. 382 - 384 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
10053 北京,首都医科大学宣武医院功能神经外科,北京市功能神经外科研究所
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-7770 |
| DOI | 10.3969/j.issn.1672-7770.2017.05.015 |
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| Summary: | 目的探讨大脑脚间核脑深部电刺激对帕金森病冻结步态的改善效果。方法采用大脑脚间核脑深部电刺激（DBS）术治疗3例药物难治性冻结步态帕金森病患者。其中2例患者采用双侧大脑脚间核DBS,1例患者采用单侧大脑脚间核联合对侧丘脑底核DBS。采用UPDRSⅢ（27-30项）对患者的轴线症状进行评分,评估效果。结果术后2例双侧DBS术的患者改善率为63.6%和66.7%;单侧DBS术患者的改善率为57.1%。3例患者术后无明显并发症。结论大脑脚间核DBS术对药物难治性帕金森病冻结步态是一种安全有效的治疗方式。 |
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| Bibliography: | parkinson disease ; gait freezing; pedunculopontine nucleus ; deep brain stimulation Objective To clarify the clinical application of pedunculopontine nucleus （PPN） stimulation in Parkinson disease. Methods Three consecutive patients with Parkinson disease complicated by severe gait freezing, postural instability and frequently falls （ all persisting even while the patient was on medication）. Two patients received bilateral stimulation without costimulation of other brain targets and one received unilateral stimulation with contralateral subthalamic nucleus （STN） stimulation. Results The primary outcome improved significantly with stimulation. Unified Parkinson Disease Rating Scale part Ⅲ （27 - 30 items ） improvement rate are 63.6%, 66.7% （bilateral stimulation） and 57.1% （unilateral stimulation） respectively. There were no permanent operative complications. Conclusion Stimulation of PPN may be beneficial for the subgroup of patients with Parkinson disease who experience severe gait freezing and postural insta |
| ISSN: | 1672-7770 |
| DOI: | 10.3969/j.issn.1672-7770.2017.05.015 |